http://www.cnr.it/ontology/cnr/individuo/prodotto/ID185605
A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation (Articolo in rivista)
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- Label
- A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation (Articolo in rivista) (literal)
- Anno
- 1996-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/ng0696-227 (literal)
- Alternative label
DEsposito, M; Ciccodicola, A; Gianfrancesco, F; Esposito, T; Flagiello, L; Mazzarella, R; Schlessinger, D; DUrso, M (1996)
A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation
in Nature genetics (Print); Nature Publishing Group, New York (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- DEsposito, M; Ciccodicola, A; Gianfrancesco, F; Esposito, T; Flagiello, L; Mazzarella, R; Schlessinger, D; DUrso, M (literal)
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- ISI Web of Science (WOS) (literal)
- Scopus (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR,INT INST GENET & BIOPHYS,I-80125 NAPLES,ITALY
UNIV MODENA,SEZ ISTOL EMBRIOL & GENET,DIPARTIMENTO SCI MORFOL & MEDICOLEGALI,I-41100 MODENA,ITALY
WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110 (literal)
- Titolo
- A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation (literal)
- Abstract
- The X and Y chromosomes that maintain human dimorphism are thought to have descended from a single progenitor, with the Y chromosome becoming largely depleted of genes. A number of genes, however, retain copies on both X and Y chromosomes and escape the inactivation that affects most X-linked genes in somatic cells. Many of those genes are present in two pseudoautosomal regions (PARs) at the termini of the short (p)3 and long (q)4,5 arms of the sex chromosomes. For both PARs, pairing facilitates the exchange of information, ensuring the homogenisation of X and Y chromosomal material in these regions. We report here a strikingly different regulation of expression of a gene in Xq PAR. Unlike all Xp PAR genes studied so far, a synaptobrevin-like gene, tentatively named SYBL1, undergoes X inactivation. In addition, it is also inactive on the Y chromosome, thereby maintaining dosage compensation in an unprecedented way. (literal)
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