http://www.cnr.it/ontology/cnr/individuo/prodotto/ID185462
Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions (Articolo in rivista)
- Type
- Label
- Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1073/pnas.0500789102 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Jilek A; Mollay C; Tippelt C; Grassi J; Mignogna G; Müllegger J; Sander V; Fehrer C; Barra D; Kreil G. (literal)
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- Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg; Austria. Institute of Biophysics and X-Ray Structure Research, Austrian Academy of Sciences, Schmiedlstrasse 6, A-8042 Graz, Austria; Service de Pharmacologie et d'Immunologie, Ba?timent 136, Commissariat a` l'Energie Atomique Saclay, 91191 Gif sur Yvette cedex, France; and Dipartimento di Scienze Biochimiche, Universita` La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy (literal)
- Titolo
- Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions (literal)
- Abstract
- D-amino acids are present in some peptides from amphibian skin. These residues are derived from the corresponding L-amino acids present in the respective precursors. From skin secretions of Bombinae,
we have isolated an enzyme that catalyzes the isomerization of an L-Ile in position 2 of a model peptide to D-allo-Ile. In the course of this reaction, which proceeds without the addition of a cofactor, radioactivity from tritiated water is incorporated into the second position of the product. The amino acid sequence of this isomerase could be deduced from cloned cDNA and genomic DNA. After expression of this cDNA in oocytes of Xenopus laevis, isomerase activity could be detected. Polypeptides related to the frog skin enzyme are present in several vertebrate species, including humans. (literal)
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