http://www.cnr.it/ontology/cnr/individuo/prodotto/ID18536
Copper in Diseases and Treatments, and Copper-Based Anticancer Strategies (Articolo in rivista)
- Type
- Label
- Copper in Diseases and Treatments, and Copper-Based Anticancer Strategies (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/med.20174 (literal)
- Alternative label
Tisato F.; Marzano C.; Porchia M.; Pellei M.; Santini C. (2010)
Copper in Diseases and Treatments, and Copper-Based Anticancer Strategies
in Medicinal research reviews (Print); Wiley, New York (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tisato F.; Marzano C.; Porchia M.; Pellei M.; Santini C. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://onlinelibrary.wiley.com/doi/10.1002/med.20174/pdf (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- ICIS-CNR, Padova /
Dipartimento di Scienze Farmaceutiche, Universita` di Padova, Padova /
ICIS-CNR, Padova /
Dipartimento di Scienze Chimiche, Universita` di Camerino, Macerata /
Dipartimento di Scienze Chimiche, Universita` di Camerino, Macerata (literal)
- Titolo
- Copper in Diseases and Treatments, and Copper-Based Anticancer Strategies (literal)
- Abstract
- Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins involved in
energy metabolism, respiration, and DNA synthesis, notably cytochrome oxidase, superoxide dismutase,
ascorbate oxidase, and tyrosinase. The major functions of copperbiological molecules involve
oxidationreduction reactions in which they react directly with molecular oxygen to produce free
radicals. Therefore, copper requires tightly regulated homeostatic mechanisms to ensure adequate
supplies without any toxic effects. Overload or deficiency of copper is associated, respectively, with
Wilson disease (WD) and Menkes disease (MD), which are of genetic origin. Researches on Menkes and
Wilson disorders have provided useful insights in the field of copper homeostasis and in particular into
the understanding of intracellular trafficking and distribution of copper at molecular levels. Therapies
based on metal supplementation with copper histidine or removal of copper excess by means of specific
copper chelators are currently effective in treating MD and WD, respectively. Copper chelation therapy
is now attracting much attention for the investigation and treatment of various neurodegenerative
disorders such as Alzheimer, Parkinson and CreutzfeldtJakob. An excess of copper appears to be an
essential co-factor for angiogenesis. Moreover, elevated levels of copper have been found in many types
of human cancers, including prostate, breast, colon, lung, and brain. On these basis, the employment of
copper chelators has been reported to be of therapeutic value in the treatment of several types of cancers
as anti-angiogenic molecules. More recently, mixtures of copper chelators with copper salts have been
found to act as efficient proteasome inhibitors and apoptosis inducers, specifically in cancer cells.
Moreover, following the worldwide success of platinum(II) compounds in cancer chemotherapy, several
families of individual copper complexes have been studied as potential antitumor agents. These investigations, revealing the occurrence of mechanisms of action quite different from platinum drugs, head toward the development of new anticancer metallodrugs with improved specificity and decreased toxic side effects. (literal)
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