Trichothecenes NIV and DON modulate the maturation of murine dendritic cells (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Trichothecenes NIV and DON modulate the maturation of murine dendritic cells (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.toxicon.2009.06.039 (literal)

Alternative label

• D. Luongo; L. Severino; P. Bergamo; R. D'Arienzo; M. Rossi (2010)
  Trichothecenes NIV and DON modulate the maturation of murine dendritic cells
  in Toxicon (Oxf.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D. Luongo; L. Severino; P. Bergamo; R. D'Arienzo; M. Rossi (literal)

Pagina inizio

• 73 (literal)

Pagina fine

• 80 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 55 (literal)

Rivista

• Toxicon (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Scienze dell'Alimentazione, CNR Department of Pathology and Animal Health, University of Naples Federico II, via F. Delpino 1, 80137 Naples, Italy (literal)

Titolo

• Trichothecenes NIV and DON modulate the maturation of murine dendritic cells (literal)

Abstract

• Nivalenol (NIV) and Deoxynivalenol (DON), mycotoxins of the trichothecene family are considered very common food contaminants. In this work, we investigated whether the immunotoxic effects ascribed to these trichothecenes may be mediated by perturbations in the activity of dendritic cells (DCs). Murine bone marrow-derived DCs were used to evaluate the effects of NIV and DON on the LPS-induced maturation process. We found that the expression of the class 11 MHC and of the accessory CD11c molecules, but not of the costimulatory CD86 marker, was down-regulated by NIV and DON exposure in LPS-treated DCs, as well as nitric oxide (NO) production. Interestingly, NIV, but not DON, induced DC necrosis. Moreover, the analysis of the cytokine pattern showed that IL-12 and IL-10 expressions induced by LPS exposure were suppressed by both trichothecenes in a dose-dependent fashion. on the other hand, the secretion of the proinflammatory cytokine TNF-alpha was increased as a direct consequence of DON and NIV exposure. Taken together, our data indicated that the immunotoxicity of NIV and DON was related to the capacity of both trichothecenes to interfere with phenotypic and functional features of maturing DCs. (C) 2009 Elsevier Ltd. All rights reserved. (literal)

Prodotto di

• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• MAURO ROSSI (Unità di personale interno)
• DIOMIRA LUONGO (Unità di personale interno)
• PAOLO BERGAMO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• PAOLO BERGAMO (Unità di personale interno)
• MAURO ROSSI (Unità di personale interno)
• DIOMIRA LUONGO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Toxicon (Rivista)