Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC (Articolo in rivista)

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  • Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1080/03008200701820443 (literal)
Alternative label
  • Pucci-Minafra I; Cancemi P; Di Cara G; Minafra L; Feo S; Forlino A; Tira ME; Tenni R; Martini D; Ruggeri A; Minafra S (2008)
    Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC
    in Connective tissue research (Print); Routledge Journals, Taylor & Francis Ltd., Abingdon (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pucci-Minafra I; Cancemi P; Di Cara G; Minafra L; Feo S; Forlino A; Tira ME; Tenni R; Martini D; Ruggeri A; Minafra S (literal)
Pagina inizio
  • 30 (literal)
Pagina fine
  • 41 (literal)
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  • 49 (literal)
Rivista
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  • 12 (literal)
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  • 1 (literal)
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  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Oncologia Sperimentale e Applicazioni Cliniche, University of Palermo Centro di Oncobiologia Sperimentale, Palermo, Italy Dipartimento di Biochimica \"A. Castellani\", University of Pavia, Pavia, Italy Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, University of Bologna, Bologna, Italy (literal)
Titolo
  • Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC (literal)
Abstract
  • Decorin is a prototype member of the small leucine-rich proteoglycan family widely distributed in the extracellular matrices of many connective tissues, where it has been shown to play multiple important roles in the matrix assembly process, as well as in some cellular activities. A major interest for decorin function concerns its role in tumorigenesis, as growth-inhibitor of different neoplastic cells, and potential antimetastatic agent. The aim of our research was to investigate wide-ranged effects of transgenic decorin on breast cancer cells. To this purpose we utilized the well-characterized 8701-BC cell line, isolated from a ductal infiltrating carcinoma of the breast, and two derived decorin-transfected clones, respectively, synthesizing full decorin proteoglycan or its protein core. The responses to the ectopic decorin production were examined by studying morphological changes, cell proliferation rates, and proteome modulation. The results revealed new important antioncogenic potentialities, likely exerted by decorin through a variety of distinct biochemical pathways. Major effects included the downregulation of several potential breast cancer biomarkers, the reduction of membrane ruffling, and the increase of cell-cell adhesiveness. These results disclose original aspects related to the reversion of malignant traits of a prototype of breast cancer cells induced by decorin. They also raise additional interest for the postulated clinical application of decorin. (literal)
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