Acute Disseminated Encephalomyelitis: A Long-Term Prospective Study and Meta-Analysis (Articolo in rivista)

Type
Label
  • Acute Disseminated Encephalomyelitis: A Long-Term Prospective Study and Meta-Analysis (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1055/s-0031-1271656 (literal)
Alternative label
  • Pavone, P; Pettoello-Mantovano, M; Le Pira, A; Giardino, I; Pulvirenti, A; Giugno, R; Parano, E; Polizzi, A; Distefano, A; Ferro, A; Pavone, L; Ruggieri, M (2010)
    Acute Disseminated Encephalomyelitis: A Long-Term Prospective Study and Meta-Analysis
    in Neuropediatrics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pavone, P; Pettoello-Mantovano, M; Le Pira, A; Giardino, I; Pulvirenti, A; Giugno, R; Parano, E; Polizzi, A; Distefano, A; Ferro, A; Pavone, L; Ruggieri, M (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • https://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1271656 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 41 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Catania, Chair Pediat, Dept Format Proc, I-95124 Catania, Italy Univ Hosp Vittorio Emanuele, Dept Pediat, Catania, Italy Univ Foggia, Dept Pediat, Foggia, Italy Univ Catania, Dept Pediat, Unit Clin Pediat, Catania, Italy Univ Catania, Dept Math & Comp Sci, Catania, Italy Italian Natl Res Council, Inst Neurol Sci, Catania, Italy Natl Ctr Rare Dis, Super Inst Hlth, Rome, Italy ASP3, Unit Community Pediat Etna Sud, Catania, Italy Univ Catania, Dept Biomed Sci, Catania, Italy (literal)
Titolo
  • Acute Disseminated Encephalomyelitis: A Long-Term Prospective Study and Meta-Analysis (literal)
Abstract
  • Background: There are only a few series in the literature on acute disseminated encephalomyelitis (ADEM) in children. Objectives and Methods: the aims of this study were to perform (i) a prospective clinical/imaging study (1992-2009) on ADEM in children consecutively referred to our institution in Catania, Italy, and (ii) to undertake a systematic review and meta-analysis of published ADEM pediatric cohorts (> 10 cases). Results: We identified 17 patients with ADEM (incidence < 10 years of age = 1.1 per 100 000 person-years). 15 previously published cohorts were compared with our cohort: (i) systematically reviewed (750 cases); and (ii) meta-analyzed (492/750 cases). The 17 patients had the following characteristics: (a) male-to-female ratio, 1.4 (vs. 1.2-1.3 in previous cohorts); (b) mean age at presentation, 3.6 years (vs. 7.1 years in previous cohorts); (c) specific preceding triggering factor, 88 % (vs. 69-79 % in previous cohorts); (d) the most common initial signs were ataxia, seizures, headache, and thalamic syndrome; (e) brain imaging revealed > 3 lesions in 100 % (vs. 92 % in previous cohorts); (f) the outcome was good in 94 % (vs. 70-75 % in previous cohorts); and (g) 12 % relapsed once (vs. 18 % in previous cohorts). Conclusions: ADEM is generally a benign condition that mosly affects boys more than girls and rarely recurs. (literal)
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