http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184710
Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy. (Articolo in rivista)
- Type
- Label
- Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
R. D'Arienzo*, R. Stefanile*, F. Maurano*, G. Mazzarella*, E. Ricca?, R. Troncone?, S Auricchio? &
2 M. Rossi* (2011)
Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy.
in Scandinavian journal of immunology (Online)
(literal)
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- R. D'Arienzo*, R. Stefanile*, F. Maurano*, G. Mazzarella*, E. Ricca?, R. Troncone?, S Auricchio? &
2 M. Rossi* (literal)
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- *National Research Council, Institute of Food
Sciences, Avellino, Italy; ?Department of
Structural and Functional Biology, University
'Federico II' of Naples, Naples, Italy; and
?European Laboratory for Investigation of Food
Induced Diseases and Department of
Pediatrics, University 'Federico II' of Naples,
Naples, Italy (literal)
- Titolo
- Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy. (literal)
- Abstract
- Coeliac disease (CD) is a very common food-sensitive enteropathy, which is
triggered by gluten ingestion and is mediated by CD4+ T cells. In addition,
alterations in the intestinal microbiota that is normally involved in the
homeostasis of GALT (gut-associated lymphoid tissue) seem to play a role in
CD. In accordance with these findings, we previously reported that L. casei can
induce a strong enhancement of the T cell-mediated response to gliadin with-
out inducing enteropathy. In this study, we analysed the effects of L. casei
administration in a mouse model of gliadin-induced villous damage that was
recently developed and involves the inhibition of cyclo-oxygenase (COX) activ-
ities in gliadin-sensitized HLA-DQ8 transgenic mice. To address the issue, we
assessed the weight loss, the intestinal cytokine pattern, the density of CD25+
cells and morphometry of the gut mucosa. We confirmed that COX inhibition
in sensitized mice caused villus blunting, dysregulated expression of tumour
necrosis factor (TNF)-a and reduced gliadin-specific IL-2 production. Notably,
the administration of probiotic strain induced a complete recovery of villus
blunting. This finding was associated with a delay in weight decrease and a
recovery of basal TNF-a levels, whereas the numbers of CD25+ cells and the
levels of IL-2 remained unchanged. In conclusion, our data suggest that the
administration of L. casei can be effective in rescuing the normal mucosal
architecture and GALT homeostasis in a mouse model of gliadin-induced
enteropathy. (literal)
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