http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184702
Divergence of Gut Permeability and Mucosal Immune Gene Expression in Two Gluten-associated Conditions, Celiac Disease and Gluten Sensitivity. (Articolo in rivista)
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- Label
- Divergence of Gut Permeability and Mucosal Immune Gene Expression in Two Gluten-associated Conditions, Celiac Disease and Gluten Sensitivity. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Teresa Giuliano,
Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Itria Russo, Pasquale Esposito,
Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano (2011)
Divergence of Gut Permeability and Mucosal Immune Gene Expression in Two Gluten-associated Conditions, Celiac Disease and Gluten Sensitivity.
in BMC medicine
(literal)
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- Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Teresa Giuliano,
Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Itria Russo, Pasquale Esposito,
Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano (literal)
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- 1Department of Internal and Experimental Medicine Magrassi-Lanzara,
Seconda Università degli Studi di Napoli, Naples, Italy. 2Mucosal Biology
Research Center, University of Maryland School of Medicine, Baltimore, MD,
USA. 3Johns Hopkins Asthma and Allergy Center, Johns Hopkins University
School of Medicine, Baltimore, MD, USA. 4Department of Experimental
Medicine, Seconda Università di Napoli, Naples, Italy. 5Institute of Food,
Consiglio Nazionale delle Ricerche (CNR), Avellino, Italy. 6Department of
Pediatrics, Seconda Università degli Studi di Napoli, Naples, Italy. 7Servizio di
Endoscopia Digestiva, Seconda Università degli Studi di Napoli, Naples, Italy.
8Morfopatologia, Seconda Università degli Studi di Napoli, Naples, Italy. (literal)
- Titolo
- Divergence of Gut Permeability and Mucosal Immune Gene Expression in Two Gluten-associated Conditions, Celiac Disease and Gluten Sensitivity. (literal)
- Abstract
- Background: Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Glutensensitive
individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD,
but the overall clinical picture is generally less severe and is not accompanied by the concurrence of tissue
transglutaminase autoantibodies or autoimmune comorbidities. By studying and comparing mucosal expression of
genes associated with intestinal barrier function, as well as innate and adaptive immunity in CD compared with GS,
we sought to better understand the similarities and differences between these two gluten-associated disorders.
Methods: CD, GS and healthy, gluten-tolerant individuals were enrolled in this study. Intestinal permeability was
evaluated using a lactulose and mannitol probe, and mucosal biopsy specimens were collected to study the
expression of genes involved in barrier function and immunity.
Results: Unlike CD, GS is not associated with increased intestinal permeability. In fact, this was significantly reduced
in GS compared with controls (P = 0.0308), paralleled by significantly increased expression of claudin (CLDN) 4 (P =
0.0286). Relative to controls, adaptive immunity markers interleukin (IL)-6 (P = 0.0124) and IL-21 (P = 0.0572) were
expressed at higher levels in CD but not in GS, while expression of the innate immunity marker Toll-like receptor
(TLR) 2 was increased in GS but not in CD (P = 0.0295). Finally, expression of the T-regulatory cell marker FOXP3
was significantly reduced in GS relative to controls (P = 0.0325) and CD patients (P = 0.0293).
Conclusions: This study shows that the two gluten-associated disorders, CD and GS, are different clinical entities,
and it contributes to the characterization of GS as a condition associated with prevalent gluten-induced activation
of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier
function. (literal)
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