http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184684
Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments (Articolo in rivista)
- Type
- Label
- Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/ncb1180 (literal)
- Alternative label
Trucco A.; Polishchuk R.S.; Martella O.; Di Pentima A.; Fusella A.; Di Giandomenico D.; San Pietro E.; Beznoussenko G.V.; Polishchuk E.V.; Baldassarre M.; Buccione R.; Geerts W.J.;Koster A.J.; Burger K.N., Mironov A.A.; Luini A. (2004)
Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments
in Nature cell biology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Trucco A.; Polishchuk R.S.; Martella O.; Di Pentima A.; Fusella A.; Di Giandomenico D.; San Pietro E.; Beznoussenko G.V.; Polishchuk E.V.; Baldassarre M.; Buccione R.; Geerts W.J.;Koster A.J.; Burger K.N., Mironov A.A.; Luini A. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Chieti, Italy
Univ Utrecht, Inst Biomembranes, Dept Mol Cell Biol, NL-3584 CH Utrecht, Netherlands (literal)
- Titolo
- Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments (literal)
- Abstract
- The organization of secretory traffic remains unclear, mainly because of the complex structure and dynamics of the secretory pathway. We have thus studied a simplified system, a single synchronized traffic wave crossing an individual Golgi stack, using electron tomography. Endoplasmic-reticulum-to-Golgi carriers join the stack by fusing with cis cisternae and induce the formation of intercisternal tubules, through which they redistribute their contents throughout the stack. These tubules seem to be pervious to Golgi enzymes, whereas Golgi vesicles are depleted of both enzymes and cargo. Cargo then traverses the stack without leaving the cisternal lumen. When cargo exits the stack, intercisternal connections disappear. These findings provide a new view of secretory traffic that includes dynamic intercompartment continuities as key players. (literal)
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