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Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach (Articolo in rivista)

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Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach (Articolo in rivista) (literal)

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Di Domenico, F (Di Domenico, Fabio)1,2,3; Casalena, G (Casalena, Gabriella)1,2,4; Sultana, R (Sultana, Rukhsana)1,2; Cai, JA (Cai, Jian)5; Pierce, WM (Pierce, William M.)5; Perluigi, M (Perluigi, Marzia)3; Cini, C (Cini, Chiara)3; Baracca, A (Baracca, Alessandra)4; Solaini, G (Solaini, Giancarlo)4; Lenaz, G (Lenaz, Giorgio)4; Jia, J (Jia, Jia)6; Dziennis, S (Dziennis, Suzan)6; Murphy, SJ (Murphy, Stephanie J.)6; Alkayed, NJ (Alkayed, Nabil J.)6; Butterfield, DA (Butterfield, D. Allan)1,2 (2010)
Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach
in Brain research; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
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Di Domenico, F (Di Domenico, Fabio)1,2,3; Casalena, G (Casalena, Gabriella)1,2,4; Sultana, R (Sultana, Rukhsana)1,2; Cai, JA (Cai, Jian)5; Pierce, WM (Pierce, William M.)5; Perluigi, M (Perluigi, Marzia)3; Cini, C (Cini, Chiara)3; Baracca, A (Baracca, Alessandra)4; Solaini, G (Solaini, Giancarlo)4; Lenaz, G (Lenaz, Giorgio)4; Jia, J (Jia, Jia)6; Dziennis, S (Dziennis, Suzan)6; Murphy, SJ (Murphy, Stephanie J.)6; Alkayed, NJ (Alkayed, Nabil J.)6; Butterfield, DA (Butterfield, D. Allan)1,2 (literal)

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1. Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA 2. Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA 3. Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy 4. Univ Bologna, Dept Biochem G Moruzzi, I-40126 Bologna, Italy 5. Univ Kentucky, Dept Pharmacol, Lexington, KY 40506 USA 6. Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97239 USA (literal)

Titolo

Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach (literal)

Abstract

Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-specificity as putative mechanisms of regulation. To explore the function of STAT3 in the brain and the hypothesis of a gender-linked modulation of STAT3, we analyzed a neuron-specific STAT3 knockout mouse model investigating the influence of STAT3 activity in brain protein expression pattern in both males and females in the absence of neurological insult. We performed a proteomic study aimed to reveal the molecular pathways directly or indirectly controlled by STAT3 underscoring its role in brain development and maintenance. We identified several proteins, belonging to different neuronal pathways such as energy metabolism or synaptic transmission, controlled by STAT3 that confirm its crucial role in brain development and maintenance. Moreover, we investigated the different processes that could contribute to the sexual dimorphic behavior observed in the incidence of neurological and mental disease. Interestingly both STAT3 KO and gender factors influence the expression of several mitochondrial proteins conferring to mitochondrial activity high importance in the regulation of brain physiology and conceivable relevance as therapeutic target. (literal)

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