http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184344

In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress (Articolo in rivista) (literal)

Anno

2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/jnr.20879 (literal)

Alternative label

Perluigi, M (Perluigi, Marzia) 4 ; Joshi, G (Joshi, Gururaj)1-2 ; Sultana, R (Sultana, Rukhsana)1-2; Calabrese, V (Calabrese, Vittorio)3; De Marco, C (De Marco, Carlo)4 ; Coccia, R (Coccia, Raffaella)4; Cini, C (Cini, Chiara)4 ; Butterfield, DA (Butterfield, D. Allan) 1-2 (2006)
In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress
in Journal of neuroscience research; WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Perluigi, M (Perluigi, Marzia) 4 ; Joshi, G (Joshi, Gururaj)1-2 ; Sultana, R (Sultana, Rukhsana)1-2; Calabrese, V (Calabrese, Vittorio)3; De Marco, C (De Marco, Carlo)4 ; Coccia, R (Coccia, Raffaella)4; Cini, C (Cini, Chiara)4 ; Butterfield, DA (Butterfield, D. Allan) 1-2 (literal)

Pagina inizio

418 (literal)

Pagina fine

426 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

84 (literal)

Rivista

Journal of neuroscience research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA 2. Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA 3. Catania Univ, Dept Chem, Biochem Sect, I-95126 Catania, Italy 4. Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome (literal)

Titolo

In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress (literal)

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of amyloid-beta peptide (A beta), a peptide that as both oligomers and fibrils is believed to play a central role in the development and progress of AD by inducing oxidative stress in brain. Therefore, treatment with antioxidants might, in principle, prevent propagation of tissue damage and neurological dysfunction. The aim of the present study was to investigate the in vivo protective effect of the antioxidant compound ferulic acid ethyl ester (FAEE) against A beta-induced oxidative damage on isolated syn-aptosomes. Gerbils were injected intraperitoneally (i.p.) with FAEE or with dimethylsulfoxide, and synaptosomes were isolated from the brain. Synaptosomes isolated from FAEE-injected gerbils and then treated ex vivo with A beta(1-42) showed a significant decrease in oxidative stress parameters: reactive oxygen species levels, protein oxidation (protein carbonyl and 3-nitrotyrosine levels), and lipid peroxidation (4-hydroxy-2-nonenal levels). Consistent with these results, both FAEE and A beta(1-42) increased levels of antioxidant defense systems, evidenced by increased levels of heme oxygenase 1 and heat shock protein 72. FAEE led to decreased levels of inducible nitric oxide synthase. These results are discussed with potential therapeutic implications of FAEE, a brain accessible, multifunctional antioxidant compound, for AD involving modulation of free radicals generated by A beta. (c) 2006 Wiley-Liss, Inc. (literal)

Editore