Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease. (Articolo in rivista)

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Label
  • Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pulcrano M; Camera L; Pagano L; Del Vecchio S; Ferone D; Bodei L; Murgia A; Pace L; Storto G; Paganelli G; Colao A; Salvatore M; Lombardi G; Biondi B. (2008)
    Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease.
    in Journal of endocrinological investigation (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pulcrano M; Camera L; Pagano L; Del Vecchio S; Ferone D; Bodei L; Murgia A; Pace L; Storto G; Paganelli G; Colao A; Salvatore M; Lombardi G; Biondi B. (literal)
Pagina inizio
  • 352 (literal)
Pagina fine
  • 359 (literal)
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  • 31 (literal)
Rivista
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  • 8 (literal)
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  • Department of Clinical and Molecular Endocrinology and Oncology and Department of Biomorphological and Functional Sciences - University \"Federico II\" - Naples - Department of Endocrinological and Metabolic Sciences - University of Genoa - Department of Nuclear Medicine - European Insititute of Oncology - Milan - Department of Endocrinology and Medical and Surgical Sciences - Padua Medical School - ITALY (literal)
Titolo
  • Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease. (literal)
Abstract
  • The identification of patients with von Hippel-Lindau (VHL) disease dictates accurate genetic counseling of family members, whereas screening for early detection of visceral and neurological involvement is usually performed by a combination of radiological and nuclear medicine techniques such as ultrasonography or contrast-enhanced computed tomography of the upper abdomen, magnetic resonance imaging of the central nervous system and 131I-metaiodobenzylguanidine-scintigraphy. The role of 111-indium-diethylenetriaminepentaacetic acid [111In-DTPA0] octreotide scintigraphy in this clinical context has never been investigated. Here, we report imaging findings in a VHL patient and in 3 consecutive family members undergoing clinical and radiological screening that included [111In-DTPA0] octreotide scintigraphy in addition to the above-mentioned procedures. Somatostatin receptor expression was investigated in vitro by immunohistochemistry in pancreatic tumor sections. On the basis of in vivo and in vitro findings, octreotide long-acting release treatment followed by 90Y-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA0)-Tyr3-octreotide led to a lack of progression in this patient although this result is a possibility which needs to be proved by further investigation and longer follow-up. The results of this study suggest that [111In-DTPA0] octreotide scintigraphy may be helpful in the routine work-up of VHL patients for diagnostic and therapeutic purposes. (literal)
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