Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.diff.2011.10.005 (literal)

Alternative label

• Leoni Bruno Daniele a; Natoli Manuela a; Nardella Marta a; Bucci Barbara c; Zucco Flavia a; D'Agnano Igea a,b; Felsani Armando a,b (2012)
  Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc
  in Differentiation (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Leoni Bruno Daniele a; Natoli Manuela a; Nardella Marta a; Bucci Barbara c; Zucco Flavia a; D'Agnano Igea a,b; Felsani Armando a,b (literal)

Pagina inizio

• 116 (literal)

Pagina fine

• 127 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 83 (literal)

Rivista

• Differentiation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a CNR, Istituto di Biologia Cellulare e Neurobiologia, Rome, Italy. b Fondazione Santa Lucia--IRCCS, Rome, Italy. c Centro Ricerca S.Pietro, Fatebenefratelli Hospital, Rome, Italy. (literal)

Titolo

• Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc (literal)

Abstract

• Caco-2 cancer cell line is widely used to reproduce in vitro the differentiation of absorptive enterocytes of human intestinal epithelium. This cell line, when cultured over confluence for 21 days, spontaneously undergoes cell cycle arrest and differentiates with the formation of a polarized enterocyte-like monolayer. During this process, Myc protein is completely down-regulated, as occurs in normal enterocytes. Caco-2 cells differ from normal enterocytes for mutations of APC and b-catenin genes, factors known to be involved in the transcriptional control of MYC gene during enterocyte differentiation. In this paper, we investigated how Myc regulation could be achieved during Caco-2 differentiative process, notwithstanding the APC and b-catenin mutations. We highlighted the post translational regulation of Myc protein as one of the essential mechanisms that allows the exit from cell cycle and onset of differentiation of Caco-2 cells. Moreover, we found a strong correlation between Myc protein downregulation and the expression of the transcription factor Cdx2, suggesting the existence of a regulative link between these two proteins. (literal)

Prodotto di

• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Autore CNR

• Manuela Natoli (Persona)
• IGEA D'AGNANO (Persona)
• ARMANDO FELSANI (Unità di personale interno)
• Marta Nardella (Unità di personale esterno)
• MARIA FLAVIA ZUCCO (Persona)
• Bruno Daniele Leoni (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ARMANDO FELSANI (Unità di personale interno)
• IGEA D'AGNANO (Persona)
• MARIA FLAVIA ZUCCO (Persona)
• Marta Nardella (Unità di personale esterno)
• Manuela Natoli (Persona)
• Bruno Daniele Leoni (Unità di personale esterno)

Prodotto

• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Differentiation (Rivista)

Insieme di parole chiave di

• Keywords of "Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc" (Insieme di parole chiave)