http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184142
DNA binding and cytotoxicity of fluorescent curcumin-based Zn(II) complexes (Articolo in rivista)
- Type
- Label
- DNA binding and cytotoxicity of fluorescent curcumin-based Zn(II) complexes (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/c2md00261b (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pucci Daniela a; Bellini Tommaso b; Crispini Alessandra c; D'Agnano Igea d; Liguori Paola F. a;Garcia-Orduna Pilar e; Pirillo Sante a; Valentini Alessandra d; Zanchetta Giuliano b (literal)
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- a Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM Unit?a della Calabria, Dipartimento di Chimica, Universit?a della Calabria, ViaP. Bucci Cubo 14C, Italy. E-mail: d.pucci@unical.it; Fax: +390984492066; Tel: +390984492064.
b University of Milan, Dipartimento di chimica, biochimica e biotecnologie per la medicina, Via F.lli Cervi 93, 20090 Segrate (MI), Italy.
c Centro di Eccellenza CEMIF.CAL-LASCAMM, CR-INSTM Unit?a della Calabria, Dipartimento di Scienze Farmaceutiche, Universit?a della Calabria, Edificio Polifunzionale, Italy.
d Institute of Cell Biology and Neurobiology, Fondazione Santa Lucia- IRCCS, Via Fosso del Fiorano 64, 00143 Rome, Italy.
e Instituto de Sintesis Qu?imica y Cat?alisis Homog?enea, Universidad deZaragoza-CSIC. Pza., San Francisco s/n., Zaragoza, Spain. (literal)
- Titolo
- DNA binding and cytotoxicity of fluorescent curcumin-based Zn(II) complexes (literal)
- Abstract
- Two new heteroleptic pentacoordinated Zn(II) complexes (1 and 2) containing 4,40-disubstituted 2,20-
bipyridines as the main ligand and curcumin (curc) as an ancillary ligand have been synthesized,
spectroscopically and structurally characterized, and tested in vitro towards different human cancer cell
lines. While the nitrogen ligands are almost inactive, Zn(II) curc derivatives 1 and 2 show promising and
selective anticancer properties. In particular the curc Zn(II) complex 1 shows the strongest growth
inhibition in all cell lines, being even more effective than the pure curc in the LAN-5 neuroblastoma cell
line. Furthermore, the curc moiety makes the complexes 1 and 2 fluorescent, a feature enabling
investigation of their interaction with DNA through a new optical method previously tested with the
reference fluorescent intercalator ethidium bromide. This analysis demonstrates that the interaction
mode of curc, 1 and 2 with DNA in the double helix favors their alignment perpendicular to the DNA
axis, suggesting a partial inter-base intercalation of these Zn(II) complexes. (literal)
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