http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184105
A study on the role of the dorsal striatum and the nucleus accumbens in allocentric and egocentric spatial memory consolidation (Articolo in rivista)
- Type
- Label
- A study on the role of the dorsal striatum and the nucleus accumbens in allocentric and egocentric spatial memory consolidation (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1101/lm.94805 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Elvira De Leonibus; Alberto Oliverio; Andrea Mele (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Dipartimento di Genetica e Biologia Molecolare, Universita` di Roma 'La Sapienza,' 00185 Rome, Italy; 2Istituto di Neuroscienze, Sezione di Psicobiologia e Psicofarmacologia, C.N.R., 00137 Rome, Italy (literal)
- Titolo
- A study on the role of the dorsal striatum and the nucleus accumbens in allocentric and egocentric spatial memory consolidation (literal)
- Abstract
- There is now accumulating evidence that the striatal complex in its two major components, the dorsal striatum and
the nucleus accumbens, contributes to spatial memory. However, the possibility that different striatal subregions
might modulate specific aspects of spatial navigation has not been completely elucidated. Therefore, in this study,
two different learning procedures were used to determine whether the two striatal components could be
distinguished on the basis of their involvement in spatial learning using different frames of reference: allocentric and
egocentric. The task used involved the detection of a spatial change in the configuration of four objects placed in an
arena, after the mice had had the opportunity to experience the objects in a constant position for three previous
sessions. In the first part of the study we investigated whether changes in the place where the animals were
introduced into the arena during habituation and testing could induce a preferential use of an egocentric or an
allocentric frame of reference. In the second part of the study we performed focal injections of the
N-methyl-D-aspartate (NMDA) receptors' antagonist, AP-5, within the two subregions immediately after training. The
results indicate that using the two behavioral procedures, the animals rely on an egocentric and an allocentric spatial
frame of reference. Furthermore, they demonstrate that AP-5 (37.5, 75, and 150 ng/side) injections into the dorsal
striatum selectively impaired consolidation of spatial information in the egocentric but not in the allocentric
procedure. Intra-accumbens AP-5 administration, instead, impaired animals trained using both procedures. (literal)
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