http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184090
Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task (Articolo in rivista)
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- Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1101/lm.1177509 (literal)
- Alternative label
Francesca Manago`; Claudio Castellano; Alberto Oliverio; Andrea Mele; Elvira De Leonibus (2009)
Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task
in Learning & memory (Cold Spring Harbor N.Y. Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Francesca Manago`; Claudio Castellano; Alberto Oliverio; Andrea Mele; Elvira De Leonibus (literal)
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Dipartimento di Genetica e Biologia Molecolare ''C. Darwin,'' Universita` degli Studi di Roma ''La Sapienza,'' Rome 00185, Italy; 2Centro di Ricerca in Neurobiologia-D. Bovet, Universita` degli Studi di Roma ''La Sapienza,'' Rome 00185, Italy; 3Istituto di Neuroscienze-CNR, CERC, Rome 00143, Italy; 4TIGEM (Telethon Institute of Genetics and Medicine), Naples 80131, Italy (literal)
- Titolo
- Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task (literal)
- Abstract
- Recent evidence demonstrated that dopamine within the nucleus accumbens mediates consolidation of both associative
and nonassociative memories. However, the specific contribution of the nucleus accumbens subregions, core and shell,
and of D1 and D2 receptors subtypes has not been yet clarified. The aim of this study was, therefore, to directly compare
the effect of D1 and D2 dopamine receptor blockade within the core and the shell subregions of the nucleus accumbens
on memory consolidation. Using the one-trial inhibitory avoidance task in CD1 mice, we demonstrated that SCH 23390
(vehicle, 12.5, 25, 50 ng/side) administration within the core, but not the shell, impaired step-through latency 24 h after
the administration if injected immediately, but not 120 min post-training. Interestingly, sulpiride (vehicle, 25, 50 ng/
side) injection in both the core and the shell of the accumbens affected step-through latency 24 h later; also, in this case
the impairment was time dependent. These data provide the most complete and direct demonstration to date that early
consolidation of aversive memory requires D2 receptor activation in both nucleus accumbens subregions, and D1
activation selectively in the nucleus accumbens core. (literal)
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