Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease (Articolo in rivista)

Type
Label
  • Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/npp.2008.129 (literal)
Alternative label
  • Elvira De Leonibus, Francesca Manago, Francesco Giordani, Francesco Petrosino, Sebastien Lopez, Alberto Oliverio, Marianne Amalric and Andrea Mele (2008)
    Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease
    in Neuropsychopharmacology (N.Y. N.Y.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Elvira De Leonibus, Francesca Manago, Francesco Giordani, Francesco Petrosino, Sebastien Lopez, Alberto Oliverio, Marianne Amalric and Andrea Mele (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Dipartimento di Genetica e Biologia Molecolare 'C.Darwin', Universita` degli Studi di Roma 'La Sapienza', Rome, Italy; 2Centro di Ricerca in Neurobiologia-D. Bovet, Universita` degli Studi di Roma 'La Sapienza', Rome, Italy; 3Dipartimento di Fisiologia Umana e Farmacologia, Universita` degli Studi di Roma 'La Sapienza', Rome, Italy; 4Laboratoire de Neurobiologie de la Cognition, Universite´s Aix-Marseille, CNRS UMR6155, Marseille, France; 5Istituto di Neuroscienze-CNR, CERC, Rome, Italy (literal)
Titolo
  • Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease (literal)
Abstract
  • Visuo-spatial deficits are the most consistently reported cognitive abnormalities in Parkinson's disease (PD), and they are frequently associated to motor symptoms in the early stages of the disease when dopamine loss is moderate and still restricted to the caudate-putamen. The metabotropic glutamate receptor 5 (mGluR5) antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), has beneficial effects on motor symptoms in animal models of PD. However, the effects of MPEP on the cognitive deficits of the disease have never been investigated. Thus, the purpose of this study was to explore its therapeutic potentials by investigating its effects on the visuo-spatial deficits induced by 6-hydroxydopamine (6-OHDA) lesions of dorsal striatum in CD1 mice. The results demonstrated that systemic injections of MPEP (6, 12, and 24 mg/kg, i.p.) impair visuo-spatial discrimination in intact mice at high concentrations, whereas lower doses (1.5 and 3 mg/kg, i.p.) were void of effects. Nevertheless, when an ineffective dose (MPEP 3 mg/kg) was injected, either acutely or subchronically (8 days), it antagonized the visuo-spatial discrimination deficit induced by bilateral dopamine lesion of the striatum. Furthermore, the same treatment increased contralateral turning induced by L-DOPA in mice bearing unilateral 6-OHDA lesion. These results confirm the therapeutic potential of mGluR5 blockade on motor symptoms induced by reduced striatal dopamine function. Further, they demonstrate that mGluR5 blockade may also have beneficial effects on cognitive deficits induced by dopamine depletion. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it