Effetcs on melanoma cell growth of meso-tetra(4-sulfonatophenyl) porphinate derivatives (Contributo in atti di convegno)

Type
Label
  • Effetcs on melanoma cell growth of meso-tetra(4-sulfonatophenyl) porphinate derivatives (Contributo in atti di convegno) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Maria Rita Emma 1, Giovanna Barbieri 1, Lorenzo Pellerito 2, Claudia Pellerito 2, Tiziana Fiore 2 and Maria Assunta Costa 1. (2008)
    Effetcs on melanoma cell growth of meso-tetra(4-sulfonatophenyl) porphinate derivatives
    in VI Congresso Dipartimento di Biologia Cellulare e dello Sviluppo, Palermo, 18-19 Dicembre 2008
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maria Rita Emma 1, Giovanna Barbieri 1, Lorenzo Pellerito 2, Claudia Pellerito 2, Tiziana Fiore 2 and Maria Assunta Costa 1. (literal)
Pagina inizio
  • 31 (literal)
Pagina fine
  • 31 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • “Excerpts from DBCS” - VI Congresso Dipartimento di Biologia Cellulare e dello Sviluppo 18-19 Dicembre 2008 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institut of Biomedicina and Immunologia Molecolare (CNR), Via Ugo La Malfa 153, 90146, Palermo, Italy ; 2 Department of Chimica Inorganica and Analitica, University of Palermo, Viale delle Scienze, Parco D'Orleans, 90128, Palermo, Italy. (literal)
Titolo
  • Effetcs on melanoma cell growth of meso-tetra(4-sulfonatophenyl) porphinate derivatives (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-88-904055-0-1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Vincenzo Cavalieri, Fabiana Geraci, Maria Grazia Zizzo, Rosa Alduina, Giovanni Morici (literal)
Abstract
  • Studies in the field of melanoma are required to identify new molecular targets for effective anti-cancer agents. In this context, we regarded some meso-tetra(4 sulfonatophenyl) porphinate (TPPS4-) derivatives as potential anti-tumour drugs. The (Bu2Sn)2TPPS and the (Bu3Sn)4TPPS compounds studied in our laboratory trigger the melanoma cell apoptosis through the activation of MAPKs. The treatment of melanoma cells with lower concentrations of (Bu2Sn)2TPPS or of (Bu3Sn)4TPPS, 0.5 ?M and 0.08 ?M respectively, significantly reduces the growth of treated cells. We showed also a reduced amount of the ?-catenin as well as of the Myc proteins in melanoma cells treated with the concentrations as above of the (Bu2Sn)2TPPS and (Bu3Sn)4TPPS derivatives. The results obtained, suggested a role at all secondary for these compounds in the regression of the melanoma invasive-metastatic state. Moreover, we analysed some new TPPS derivatives such as (Me2Sn)2MnClTPPS, (Bu2Sn)2MnClTPPS, (Me3Sn)4MnClTPPS and (Bu3Sn)4MnClTPPS. The results obtained showed that 10 ?M of (Bu2Sn)2MnClTPPS and 1 ?M of (Bu3Sn)4MnClTPPS are clearly cytotoxic for melanoma cells. The DNA fragmentation analysis strongly suggested that these compounds induced the apoptotic death of treated melanoma cells. We also identified the concentrations of these compounds which reduce the growth of treated melanoma cells: 10 ?M for (Me3Sn)4MnClTPPS and 0.1 ?M both for (Bu2Sn)2MnClTPPS and for (Bu3Sn)4MnClTPPS. (literal)
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