Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Giovagnini L. 1, Ronconi L. 1, Aldinucci D. 2, Lorenzon D. 2, Sitran S. 3, Fregona D. 1 (2005)
  Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes
  in Journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Giovagnini L. 1, Ronconi L. 1, Aldinucci D. 2, Lorenzon D. 2, Sitran S. 3, Fregona D. 1 (literal)

Pagina inizio

• 1588 (literal)

Pagina fine

• 1595 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 48 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Chemical Sciences, University of Padua 2. Clinical and Experimental Hematology Research Unit, C.R.O. Research Area, I.R.C.C.S., Aviano 3. Institute of Inorganic and Surfaces Chemistry, C.N.R. Research Area Padua (literal)

Titolo

• Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes (literal)

Abstract

• This work reports on the synthesis, characterization and in vitro cytotoxic activity of some new platinum(II), palladium(II) and gold(III) derivatives of methylsarcosinedithiocarbamate and its S-methyl ester, in order to study their behavior as potential antitumor agents. The biological activity of these compounds, as determined by growth inhibition and apoptosis induction, has been investigated in both human leukemic promyelocites HL60 and human squamous cervical adenocarcinoma HeLa cell lines, and their activity compared to the well known platinum-based anticancer agent cisplatin. On the basis of these experimental results, ƒËPd(MSDT)XƒÍn (MSDT = methylsarcosinedithiocarbamate; X = Cl, Br) complexes determine a strong dose-dependent growth inhibition of both HL60 and HeLa cells, with IC50 values slightly higher than those recorded for cisplatin; moreover, ƒËAu(MSDT)X2] activity appears significantly higher or, at least, comparable to that of the reference drug. Exposure of both cell lines to ƒËPd(MSDT)XƒÍn and ƒËAu(MSDT)X2] complexes induces apoptosis, as determined by Apo2.7 assay. (literal)

Prodotto di

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Conoscenza materica di siti, manufatti, descrizione del loro stato di conservazione e metodologie di intervento. (PC.P03.002.001) (Modulo)

Autore CNR

• SERGIO SITRAN (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Conoscenza materica di siti, manufatti, descrizione del loro stato di conservazione e metodologie di intervento. (PC.P03.002.001) (Modulo)

Autore CNR di

• SERGIO SITRAN (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes" (Insieme di parole chiave)