http://www.cnr.it/ontology/cnr/individuo/prodotto/ID183349
IL-15 inhibits IL-7Ralpha expression by memory-phenotype CD8(+) T cells in the bone marrow (Articolo in rivista)
- Type
- Label
- IL-15 inhibits IL-7Ralpha expression by memory-phenotype CD8(+) T cells in the bone marrow (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/eji.201142019 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Angela Caterina Quinci; Sara Vitale; Elisabetta Parretta; Alessandra Soriani; Maria Luisa Iannitto; Marco Cippitelli; Cinzia Fionda; Slivia Bulfone-Paus; Angela Santoni; Francesca Di Rosa. (literal)
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- Qunci AC; Vitale S; Parretta E; Soriani A; Iannitto ML; Cippitelli M; Fionda C; Santoni A =Department of Molecular Medicine-Istituto Pasteur Fondazione Cenci-Bolognetti, University of Rome \"Sapienza\", Rome, Italy
Vitale S; Bulfone-Paus S = Department of Immunology and Cell Biology, Research Center Borstel, Germany;
Cippitelli M; Fionda C = Laboratory of Immunology, Regina Elena Cancer Institute, Rome, Italy
Bulfone-Paus S =School of Translational Medicine, University of Manchester, Manchester, UK (literal)
- Titolo
- IL-15 inhibits IL-7Ralpha expression by memory-phenotype CD8(+) T cells in the bone marrow (literal)
- Abstract
- CD127 is the IL-7 receptor ?-chain and its expression is tightly regulated during T-cell differentiation. We previously showed that the bone marrow (BM) is a key organ for proliferation and maintenance of both antigen-specific and CD44(high) memory CD8(+) T cells. Interestingly, BM memory CD8(+) T cells express lower levels of membrane CD127 than do the corresponding spleen and lymph node cells. We investigated the requirements for CD127 downmodulation by CD44(high) memory-phenotype CD8(+) T cells in the BM of C57BL/6 mice. By comparing genetically modified (i.e. CD127tg, IL-7 KO, IL-15 KO, IL-15R? KO) with wild-type (WT) mice, we found that the key molecule regulating CD127 downmodulation was IL-15 but not IL-7, and that the intact CD127 gene was required, including the promoter. Indeed, CD127 mRNA transcript levels were lower in CD44(high) CD8(+) T cells from the BM than in those from the spleen of WT mice, indicating organ-specific regulation. Although levels of the CD127 transactivator Foxo1 were low in BM CD44(high) CD8(+) T cells, Foxo1 was not involved in IL-15-induced CD127 downmodulation. Thus, recirculating CD44(high) CD8(+) T cells passing through the BM transiently downregulate CD127 in response to IL-15, with implications for human therapies acting on the IL-7/CD127 axis, for example cytokine treatments in cancer patients. (literal)
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