http://www.cnr.it/ontology/cnr/individuo/prodotto/ID183218

Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease (Articolo in rivista) (literal)

Anno

2005-01-01T00:00:00+01:00 (literal)

Alternative label

Pellegrino T; Storto G; Filardi PP; Sorrentino AR; Silvestro A; Petretta M; Brevetti G; Chiariello M; Salvatore M; Cuocolo A (2005)
Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease
in The Journal of nuclear medicine (1978); Society of Nuclear Medicine Inc., Reston (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pellegrino T; Storto G; Filardi PP; Sorrentino AR; Silvestro A; Petretta M; Brevetti G; Chiariello M; Salvatore M; Cuocolo A (literal)

Pagina inizio

1997 (literal)

Pagina fine

2002 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

46 (literal)

Rivista

?The ?Journal of nuclear medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

12 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy; Institute of Biostructure and Bioimages, National Council of Research, Napoli, Italy; Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy (literal)

Titolo

Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease (literal)

Abstract

The aim of this study was to assess the relationship between brachial artery flow-mediated dilation (FMD) and coronary flow reserve (CFR) in patients with peripheral artery disease (PAD). Methods: Thirty patients who had PAD, who showed no cardiac symptoms, and who had normal stress SPECT cardiac imaging results and 28 control subjects underwent brachial artery FMD assessment by ultrasound and dipyridamole Tc-99m-sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first-transit counts in the pulmonary artery and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of MBF at stress to MBF at rest. Results: Patients with PAD were separated into 2 groups according to the median value of overall FMD (6.85%): group 1 (n = 15) with FMD above the median (mean +/- SD, 8.78% +/- 1.3%) and group 2 (n = 15) with FMD below the median (mean +/- SD, 5.14% +/- 0.94%). FMD was significantly higher in control subjects (11.4% +/- 3.4%) than in both groups of PAD patients (P < 0.001 for both). In control subjects, estimated CFR was 2.2 +/- 0.4-significantly higher than CFR in both groups of PAD patients (P < 0.001 for both). In addition, in PAD patients of group 1, estimated CFR was 1.5 +/- 0.4-higher than CFR in group 2 (1.0 +/- 0.4) (P < 0.01). When all PAD patients were considered, a significant correlation between FMD and estimated CFR was observed (r = 0.56, P < 0.005). Conclusion: Estimated CFR is significantly lower in patients with PAD than in control subjects, and CFR impairment correlates with the degree of peripheral endothelial dysfunction. (literal)

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