http://www.cnr.it/ontology/cnr/individuo/prodotto/ID183140

Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.Duclcard.2007.08.003 (literal)

Alternative label

Ciampi Q; Betocchi S; Losi MA; Ferro A; Cuocolo A; Lombardi R; Villari B; Chiariello M (2007)
Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy
in Journal of nuclear cardiology; Mosby-Elsevier, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Ciampi Q; Betocchi S; Losi MA; Ferro A; Cuocolo A; Lombardi R; Villari B; Chiariello M (literal)

Pagina inizio

869 (literal)

Pagina fine

875 (literal)

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14 (literal)

Rivista

Journal of nuclear cardiology (Rivista)

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7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy; Division of Cardiology, Fatebenefratelli Hospital, Benevento, Italy; Department of Morphological and Functional Sciences, \"Federico II\" University School of Medicine, Naples, Italy (literal)

Titolo

Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy (literal)

Abstract

Background. Abnormal blood-pressure response during exercise occurs in about one third of patients with hypertrophic cardiomyopathy (HCM), and it has been associated with a high risk of sudden cardiac death. We assessed the hemodynamics of exercise in HCM patients with abnormal blood-pressure response by using ambulatory radionuclide monitoring (VEST) of left-ventricular (LV) function, and exercise tolerance by oxygen consumption. Methods. Twenty-two HCM patients uderwent treadmill exercise during VEST monitoring. A cardiopulmonary exercise test was performed a few days after. The VEST data were averaged for I minute. Stroke volume, cardiac output, and systemic vascular resistance were expressed as percent of baseline. Exercise tolerance was assessed as maximal oxygen consumption. Results. In eight HCM patients (36%) with an abnormal blood-pressure response, end-systolic volume increased more (52% +/- 21% vs 31% +/- 28%, P = .012), and the ejection fraction (-31% +/- 17% vs -14% +/- 22%, P = .029) and stroke volume (-21% +/- 21% vs 3% +/- 28%, P = .026) fell more, than in patients with normal response. Cardiac output increased less in the former patients (49% +/- 44% vs 94% +/- 44%, P = .012). Systemic vascular resistance decreased similarly, irrespective of blood-pressure response (-28% +/- 26% vs -34% +/- 26%, P = N.S.). Percent of maximal predicted oxygen consumption was lower in HCM patients with an abnormal blood-pressure response (63% +/- 11% vs 78% +/- 15%, P = .025). Conclusions. In HCM patients, abnormal blood-pressure response was associated with exercise-induced LV systolic dysfunction and impairment in oxygen consumption. This may cause hemodynamic instability, associated with a high risk of sudden cardiac death. (literal)

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