Non-neuronal components of cholinergic system in peripheral blood T-cells of COPD patients (Contributo in atti di convegno)

Type
Label
  • Non-neuronal components of cholinergic system in peripheral blood T-cells of COPD patients (Contributo in atti di convegno) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mirella Profita,1; Loredana Riccobono,1; Angela Marina Montalbano,1; Maria Ferraro,1; Stefania Gerbino,1; Andreina Bruno,1; Giusy Daniela Albano,1; Michael Paul Pieper,2; Mark Gjomarkaj 1. (2009)
    Non-neuronal components of cholinergic system in peripheral blood T-cells of COPD patients
    in 19th ERS Annual congress, Vienna, Austria, September 12-16,2009
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mirella Profita,1; Loredana Riccobono,1; Angela Marina Montalbano,1; Maria Ferraro,1; Stefania Gerbino,1; Andreina Bruno,1; Giusy Daniela Albano,1; Michael Paul Pieper,2; Mark Gjomarkaj 1. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • Volume 34/Supplement 53 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 IBIM, CNR, Palermo, Italy; 2 Pharma GmbH, Boehringer Ingelheim, Biberach, Germany. (literal)
Titolo
  • Non-neuronal components of cholinergic system in peripheral blood T-cells of COPD patients (literal)
Abstract
  • Although the main causes of systemic inflammation in COPD remain to be elucidated, circulating cells are strongly involved in the pathogenesis of COPD. Non-neuronal components of cholinergic system may participate in the airway inflammation of COPD despite their role in the systemic compartment remains not fully elucidated. We evaluated: 1) the muscarinic M1, M2, M3 receptors and Choline-AcetylTransferase (ChAT) expression, the ACh-binding, and the cell apoptosis (on the basis of annexin V binding) in peripheral blood T cells (PBTs) from COPD patients, control smokers and controls using flow-cytometry; 2) the serum levels of ACh in the same groups of subjects; 3) the effects of Tiotropium (Spiriva®), alone or in combination with Fluticasone Propionate and Salmeterol, on the PBTs apoptosis in COPD patients. We showed that: 1) M1, M2, M3 and ChAT expression as well as the ACh binding and the levels of serum ACh are increased in Smokers and COPD patients when compared to controls; 2) T-cell apoptosis (CD8+) is increased in Smokers and COPD patients when compared to controls; 3) Fluticasone Proprionate (FP) increases PBTs apoptosis and the combination of FP and Tiotropium further increases it. This study suggests that the altered expression of the non-neuronal components of cholinergic system in circulating PBTs might contribute to their apoptosis. Further studies are necessary to assess the clinical significance of this event. (literal)
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