Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (Articolo in rivista)

Type
Label
  • Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ronconi L. 1, Marzano C. 2, Russo U. 3, Sitran S. 4, Graziani R. 5, Fregona D. 6 (2002)
    Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine
    in Journal of inorganic biochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ronconi L. 1, Marzano C. 2, Russo U. 3, Sitran S. 4, Graziani R. 5, Fregona D. 6 (literal)
Pagina inizio
  • 413 (literal)
Pagina fine
  • 420 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 91 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 4, ICIS-CNR; 1,2,3,5,6 UNI-Padova (literal)
Titolo
  • Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (literal)
Abstract
  • The synthesis and characterization of new coordination compound of some diorganotins(IV) with N-methylglycine (sarcosine) are reported; all these derivatives mainly tend to assume a chelate structure. As single crystals were not obtained, a large number of experimental techniques were used to accomplish a definitive characterization and determination of their structure. Results obtained by 1H/119Sn NMR, FT-IR and 119mSn-Mössbauer spectroscopy and thermogravimetric analysis allow us to deduce the pentacoordination for 1:1 (Sn/sarcosine) derivatives [R2SnCl2(Sar)]+Cl— (R = Me, n-Bu) in a trigonal-bipyramidal structure, and the hexacoordination for 1:2 complexes [R’2Sn(Sar)2]2+2Cl— (R’ = Me, n-Bu, Ph) in an octahedral structure; however, the probability of partially or totally non-chelate structures for some adducts increases with the steric hindrance of the R (R’ groups and the number of the sarcosine molecules bound to the tin atom, so that they give rise to fluxional equilibria in solution. Finally, the synthesized compounds have been tested for in vitro cytotoxic activity against human adenocarcinoma HeLa cells showing, in some cases, strong activity even at low concentration. (literal)
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