http://www.cnr.it/ontology/cnr/individuo/prodotto/ID18300
Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (Articolo in rivista)
- Type
- Label
- Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Ronconi L. 1, Marzano C. 2, Russo U. 3, Sitran S. 4, Graziani R. 5, Fregona D. 6 (2002)
Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine
in Journal of inorganic biochemistry
(literal)
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- Ronconi L. 1, Marzano C. 2, Russo U. 3, Sitran S. 4, Graziani R. 5, Fregona D. 6 (literal)
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- ISI Web of Science (WOS) (literal)
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- 4, ICIS-CNR; 1,2,3,5,6 UNI-Padova (literal)
- Titolo
- Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine (literal)
- Abstract
- The synthesis and characterization of new coordination compound of some
diorganotins(IV) with N-methylglycine (sarcosine) are reported; all these
derivatives mainly tend to assume a chelate structure. As single crystals
were not obtained, a large number of experimental techniques were used to
accomplish a definitive characterization and determination of their
structure. Results obtained by 1H/119Sn NMR, FT-IR and 119mSn-Mössbauer
spectroscopy and thermogravimetric analysis allow us to deduce the
pentacoordination for 1:1 (Sn/sarcosine) derivatives [R2SnCl2(Sar)]+Cl (R
= Me, n-Bu) in a trigonal-bipyramidal structure, and the hexacoordination
for 1:2 complexes [R2Sn(Sar)2]2+2Cl (R = Me, n-Bu, Ph) in an octahedral
structure; however, the probability of partially or totally non-chelate
structures for some adducts increases with the steric hindrance of the R
(R groups and the number of the sarcosine molecules bound to the tin
atom, so that they give rise to fluxional equilibria in solution. Finally,
the synthesized compounds have been tested for in vitro cytotoxic activity
against human adenocarcinoma HeLa cells showing, in some cases, strong
activity even at low concentration. (literal)
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