http://www.cnr.it/ontology/cnr/individuo/prodotto/ID182847
Definition, epidemiology and natural history of COPD (Articolo in rivista)
- Type
- Label
- Definition, epidemiology and natural history of COPD (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1183/09031936.00082507 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giovanni Viegi; Francesco Pistelli; D.L. Sherrill; Sara Maio; Sandra Baldacci; Laura Carrozzi (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Francesco Pistelli, Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, and Cardiothoracic Dept, University of Pisa, Pisa, Italy;
D.L. Sherrill, Arizona Clinical Research Training Program, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA;
Laura Carrozzi, Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, and Cardiothoracic Dept, University of Pisa, Pisa, Italy. (literal)
- Titolo
- Definition, epidemiology and natural history of COPD (literal)
- Abstract
- Chronic obstructive pulmonary disease (COPD) is the fifth cause of morbidity and
mortality in the developed world and represents a substantial economic and social burden.
Patients experience a progressive deterioration up to end-stage COPD, characterised by very
severe airflow limitation, severely limited and declining performance status with chronic
respiratory failure, advanced age, multiple comorbidities and severe systemic manifestations/
complications.
COPD is frequently underdiagnosed and under-treated. Today, COPD develops earlier in life
and is less gender specific. Tobacco smoking is the major risk factor for COPD, followed by
occupation and air pollution. Severe deficiency for a1-antitrypsin is rare; several phenotypes are
being associated with elevated risk for COPD in the presence of risk factor exposure. Any patient
presenting with cough, sputum production or dyspnoea should be assessed by standardised
spirometry. Continued exposure to noxious agents promotes a more rapid decline in lung function
and increases the risk for repeated exacerbations, eventually leading to end-stage disease.
Without major efforts in prevention, there will be an increasing proportion of end-stage patients
who can live longer through long-term oxygen therapy and assisted ventilation, but with elevated
suffering and huge costs. Smoking prevention and smoking cessation are the most important
epidemiological measurements to counteract chronic obstructive pulmonary disease epidemics. (literal)
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