Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (Contributo in atti di convegno)

Type
Label
  • Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (Contributo in atti di convegno) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • E. Pace1; M.Ferraro1; L.Siena1; M.Melis1; A.M.Montalbano1; M.Johnson2; M.R. Bonsignore3; G.Bonsignore1; M.Gjomarkaj1 (2007)
    Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells
    in ERS Annual Congress, Stockolm (Sweden), September 15-19, 2007
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • E. Pace1; M.Ferraro1; L.Siena1; M.Melis1; A.M.Montalbano1; M.Johnson2; M.R. Bonsignore3; G.Bonsignore1; M.Gjomarkaj1 (literal)
Pagina inizio
  • 217s E1334 (literal)
Pagina fine
  • 217s (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 30 (suppl.51) (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1IBIM, ConsiglioNazionale delle Ricerche,Palermo,Italy; 2GlaxoSmithKline ResearchandDevelopment Ltd, GlaxoSmithKline,Greenford,Middlesex,UnitedKingdom; 3Dipartimento d MedicinaPneumologica,FisiologiaeMutrizione(DIMPEFINU),Universit`a degliStudidiPalermo,Palermo,Italy (literal)
Titolo
  • Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (literal)
Abstract
  • Airwayepitheliumisemergingasaregulatorofinnateimmuneresponsestoa varietyofinsultsincludingcigarettesmoke.Themaingoalofthisstudywas to exploretheeffectsofcigarettesmokeextracts(CSE)inthetolllikereceptor (TLR) expressionandactivationinahumanbronchialepithelialcellline(16- HBE). CSEincreasedtheexpressionofTLR4andtheLPSbinding,theNFkB activation,thereleaseofIL-8andthechemotacticactivitytowardneutrophilsbut did notinducetheTLR2expressionandtheERK1/2activation.LPSincreasedthe expressionofTLR4andinducedbothNFkBandErk1/2activation.Thecombined exposureof16-HBEtoCSEandLPS,furtherincreasedIL-8releaseandthe chemotactic activitytowardneutrophils.Theseadditiveeffectswereassociated to ERKactivationratherthantoNFkBactivation.Furthermore,CSEdecreased the constitutiveIP-10releaseandcounteractedtheeffectofLPSininducing IP-10 release.Inconclusion,cigarettesmokecontributestotheaccumulationof neutrophils withintheairwaysofsmokersbyincreasingtheexpressionofTLR4 and bypreferentiallyorientatingTLR4activationtowardactivationofERKand IL-8 production. SupportedbyGlaxoSmithKline. (literal)
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