http://www.cnr.it/ontology/cnr/individuo/prodotto/ID182833
Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (Contributo in atti di convegno)
- Type
- Label
- Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (Contributo in atti di convegno) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
E. Pace1; M.Ferraro1; L.Siena1; M.Melis1; A.M.Montalbano1; M.Johnson2;
M.R. Bonsignore3; G.Bonsignore1; M.Gjomarkaj1 (2007)
Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells
in ERS Annual Congress, Stockolm (Sweden), September 15-19, 2007
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. Pace1; M.Ferraro1; L.Siena1; M.Melis1; A.M.Montalbano1; M.Johnson2;
M.R. Bonsignore3; G.Bonsignore1; M.Gjomarkaj1 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1IBIM, ConsiglioNazionale
delle Ricerche,Palermo,Italy; 2GlaxoSmithKline ResearchandDevelopment
Ltd, GlaxoSmithKline,Greenford,Middlesex,UnitedKingdom; 3Dipartimento
d MedicinaPneumologica,FisiologiaeMutrizione(DIMPEFINU),Universit`a
degliStudidiPalermo,Palermo,Italy (literal)
- Titolo
- Cigarette smoke increases TLR4 expression and modifies LPS mediated responses in airway epithelial cells (literal)
- Abstract
- Airwayepitheliumisemergingasaregulatorofinnateimmuneresponsestoa
varietyofinsultsincludingcigarettesmoke.Themaingoalofthisstudywas
to exploretheeffectsofcigarettesmokeextracts(CSE)inthetolllikereceptor
(TLR) expressionandactivationinahumanbronchialepithelialcellline(16-
HBE). CSEincreasedtheexpressionofTLR4andtheLPSbinding,theNFkB
activation,thereleaseofIL-8andthechemotacticactivitytowardneutrophilsbut
did notinducetheTLR2expressionandtheERK1/2activation.LPSincreasedthe
expressionofTLR4andinducedbothNFkBandErk1/2activation.Thecombined
exposureof16-HBEtoCSEandLPS,furtherincreasedIL-8releaseandthe
chemotactic activitytowardneutrophils.Theseadditiveeffectswereassociated
to ERKactivationratherthantoNFkBactivation.Furthermore,CSEdecreased
the constitutiveIP-10releaseandcounteractedtheeffectofLPSininducing
IP-10 release.Inconclusion,cigarettesmokecontributestotheaccumulationof
neutrophils withintheairwaysofsmokersbyincreasingtheexpressionofTLR4
and bypreferentiallyorientatingTLR4activationtowardactivationofERKand
IL-8 production.
SupportedbyGlaxoSmithKline. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi