http://www.cnr.it/ontology/cnr/individuo/prodotto/ID18255
Orgranotin(IV) complexes of ethylsarcosine hydrochloride: synthesis, characterization and in vitro cytotoxic activity (Articolo in rivista)
- Type
- Label
- Orgranotin(IV) complexes of ethylsarcosine hydrochloride: synthesis, characterization and in vitro cytotoxic activity (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Ronconi L.1, Marzano C.2, Russo U.1, Sitran S.3, Graziani R.1, Fregona D.1 (2003)
Orgranotin(IV) complexes of ethylsarcosine hydrochloride: synthesis, characterization and in vitro cytotoxic activity
in Applied organometallic chemistry
(literal)
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- Ronconi L.1, Marzano C.2, Russo U.1, Sitran S.3, Graziani R.1, Fregona D.1 (literal)
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- ISI Web of Science (WOS) (literal)
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- 1. Dipartimento di Chimica Inorganica, Metallorganica ed Analitica dellUniversita di Padua
2. Dipartimento di Scienze Farmaceutiche dellUniversitadi Padua
3. Istituto di Chimica e Tecnologie Inorganiche e dei Materiali Avanzati, CNR - Padua (literal)
- Titolo
- Orgranotin(IV) complexes of ethylsarcosine hydrochloride: synthesis, characterization and in vitro cytotoxic activity (literal)
- Abstract
- The synthesis and characterization of new coordination compounds of some organotin(IV) chlorides with ethylsarcosine hydrochloride (N-methylglycine ethyl ester hydrochloride) is reported; the ligand molecules appear to be bound to the tin atoms through the carbonyl oxygen atoms by means of dative bonds. As single crystals were not obtained, a number of experimental techniques were used to accomplish a definitive characterization and determination of their structure. The results obtained by 1H, 13C, 119Sn NMR, FT-IR and 119mSn Mössbauer spectroscopy and thermogravimetric analysis suggested pentacoordination for the 1:1 (Sn:ligand (ESH)) derivatives, [R2SnCl2(ESH)]+Cl-, in a trigonal bipyramidal (TBP) structure, and hexacoordination for the 1:2 complexes, [R2SnCl2(ESH)2]2+2Cl-, in an octahedral structure (R = Me, n-Bu, Ph; ESH = protonated ethylsarcosine, CH3CH2O(O)CCH2N(CH3)H2+). The triphenyltin(IV) chloride ethylsarcosine hydrochloride derivative exists only as a 1:1 pentacoordinated adduct in a strongly distorted TBP structure. Finally, the compounds have been tested for in vitro cytotoxic activity against human adenocarcinoma HeLa cells, showing, in some cases, a high potency, even at low concentration. (literal)
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