http://www.cnr.it/ontology/cnr/individuo/prodotto/ID182534
The protective role of estrogen-receptor-beta in retinal excitotoxicity. (Contributo in atti di convegno)
- Type
- Label
- The protective role of estrogen-receptor-beta in retinal excitotoxicity. (Contributo in atti di convegno) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Cascio C.; Russo D.; Guarneri R.; Passantino R.; Galizzi G.; Deidda I.; Guarneri P. (2008)
The protective role of estrogen-receptor-beta in retinal excitotoxicity.
in 6th Forum of European Neuroscience, Ginevra (Svizzera), 12-16 luglio 2008
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cascio C.; Russo D.; Guarneri R.; Passantino R.; Galizzi G.; Deidda I.; Guarneri P. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Presente anche in formato digitalizzato (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
- 6th Forum of European Neuroscience (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
- FENS Abstr. vol 4, 2008 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR - Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\", Palermo, Italy (literal)
- Titolo
- The protective role of estrogen-receptor-beta in retinal excitotoxicity. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
- Abstract
- The likelihood that 17beta-estradiol (E2) may exert its neuroprotective actions in retinal diseases is
going to be considered on the evidence of its beneficial effects in retinal ischemia, light-induced
photoreceptor degeneration, retinitis pigmentosa, AMD and experimental glaucoma. Recently, we
have showed E2 synthesis in the adult male retina and identified the estrogen-synthesizing
aromatase enzyme primarily located in the outer plexiform and inner nuclear layers, thus
substantiating the role of E2 in the retina as well as in brain, independently of sex. Furthermore, both
estrogen receptor subtypes, ERalpha and ERbeta, were found throughout the retina with the highest
intensity in the inner retina. To explore whether retinal excitotoxic insult may interfere with E2
synthesis and function, we examined the expression and activity of aromatase and ERalpha and
ERbeta in retinal explants of adult male rats exposed to NMDA receptor-mediated toxicity. We found
that insulted retinas had a low level of E2, a reduced ability in converting testosterone into E2 and an
unchanged expression of aromatase; however, blockers of NMDA receptor-induced calcium influx
restored E2 levels. Expressions of ERalfa and ERbeta were respectively reduced and enhanced, and
the exogenous application of E2 prevented only ERalpha reduction. After the excitotoxic insult, a
selective ERbeta ligand was most effective in halting retinal toxicity when compared to
ERalpha-mediated protective effects observed only at micromolar E2 concentrations. These results
suggest that retinal NMDA receptor-induced calcium-mediated mechanisms interfere with aromatase
activity and affect endogenous E2 synthesis, this may result in a different regulation of estrogen
receptors and a favoured ERbeta function. (literal)
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