Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ccr.2007.01.014 (literal)

Alternative label

• Vecchione, Andrea; Baldassarre, Gustavo; Ishii, Hideshi; Nicoloso, Milena S.; Belletti, Barbara; Petrocca, Fabio; Zanesi, Nicola; Fong, Louise Y. Y.; Battista, Sabrina; Guarnieri, Daniela; Baffa, Raffaele; Alder, Hansjuerg; Farber, John L.; Donovan, Peter J.; Croce, Carlo M. (2007)
  Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development
  in Cancer cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vecchione, Andrea; Baldassarre, Gustavo; Ishii, Hideshi; Nicoloso, Milena S.; Belletti, Barbara; Petrocca, Fabio; Zanesi, Nicola; Fong, Louise Y. Y.; Battista, Sabrina; Guarnieri, Daniela; Baffa, Raffaele; Alder, Hansjuerg; Farber, John L.; Donovan, Peter J.; Croce, Carlo M. (literal)

Pagina inizio

• 275 (literal)

Pagina fine

• 289 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=1AFdc42BEpnP3oDAL5j&page=1&doc=1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Cancer cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Univ Roma La Sapienza, Osped Santo Andrea, Fac MEd 2, Div Pathol, I-00185 Rome, Italy IRCCS, CRO 2, Div Expt Oncol, I-33081 Aviano, Italy Jichi Med Sch, Ctr Mol Med, Toxhigi 3290498, Japan Univ Naples Federico II, Dept Mat & Prod Engn, I-80139 Naples, Italy CNR, Composite & Biomed Mat Inst, I-80125 Naples, Italy Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA (literal)

Titolo

• Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development (literal)

Abstract

• The FEZ1/LZTS1 (LZTS1) protein is frequently downregulated in human cancers of different histotypes. LZTS1 is expressed in normal tissues, and its introduction in cancer cells inhibits cell growth and suppresses tumorigenicity, owing to an accumulation of cells in G2/M. Here we define its role in cell cycle regulation and tumor progression by generating Lzts1 knock-out mice. In Lzts1-/- mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase resulting in decreased Cdk1 activity. As a consequence, -/- MEFs showed accelerated mitotic progression, resistance to taxol- and nocodazole-induced M phase arrest, and improper chromosome segregation. Accordingly, Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice. (literal)

Prodotto di

• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)
• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• SABRINA BATTISTA (Unità di personale interno)

Incoming links:

Prodotto

• Institute Experimental Endocrinology and Oncology \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)

Autore CNR di

• SABRINA BATTISTA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer cell (Rivista)