http://www.cnr.it/ontology/cnr/individuo/prodotto/ID182045

Epidemiology of cleft palate in Europe: implications for genetic research (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Epidemiology of cleft palate in Europe: implications for genetic research (Articolo in rivista) (literal)

Anno

2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1597/02-074.1 (literal)

Alternative label

Bianchi, Fabrizio; Rubini, Michele; Calzolari, Elisa; Neville, Amanda J.; Ritvanen, Annukka (2004)
Epidemiology of cleft palate in Europe: implications for genetic research
in The Cleft palate-craniofacial journal (Print); Allen Press Inc., Lawrence (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Bianchi, Fabrizio; Rubini, Michele; Calzolari, Elisa; Neville, Amanda J.; Ritvanen, Annukka (literal)

Pagina inizio

244 (literal)

Pagina fine

249 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.cpcjournal.org/doi/abs/10.1597/02-074.1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

41 (literal)

Rivista

?The ?Cleft palate-craniofacial journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

03 (literal)

Note

ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Dr. Calzolari is Professor of Genetic Medicine, Ms. Neville is a Scientific Secretary, and Dr. Rubini is a Senior Researcher, Genetic Medicine Section, Department of Experimental Medicine and Diagnostics, University of Ferrara, Ferrara, Italy. Dr. Bianchi is a Senior Researcher, Unit of Epidemiology, Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy. Dr. Ritvanen is a Senior Researcher, The Finnish Register of Congenital Malformations, The National Research and Development Centre for Welfare and Health, Helsinki, Finland. The EUROCAT Working group: Helen Dolk, Professor of Epidemiology, EUROCAT Central Registry Leader, University of Ulster, Co Antrim, Northern Ireland, United Kingdom (literal)

Titolo

Epidemiology of cleft palate in Europe: implications for genetic research (literal)

Abstract

bjective: To describe the epidemiology of cleft palate (CP) in Europe. Design and Setting: A descriptive epidemiological study on 3852 cases of CP, identified (1980 through 1996) from more than 6 million births from the EUROCAT network of 30 registers in 16 European countries. Results: Significant differences in prevalence in Europe between registries and within countries were observed. A total of 2112 (54.8%) CP cases occurred as isolated, 694 (18.0%) were associated with other defects such as multiple congenital anomalies, and 1046 (27.2%) were in recognized conditions. The study confirmed the tendency toward female prevalence (sex ratio [SR] = 0.83), particularly among isolated cases (SR = 0.78) even if SR inversion is reported in some registries. A specific association with neural tube defects (NTDs) in some registers is reported. Conclusion: The differences identified in Europe (prevalence, sex, associated anomalies) can be only partially explained by methodological reasons because a common methodology was shared among all registries for case ascertainment and collection, and CP is an easy detectable condition with few induced abortions. The complex model of inheritance and the frequently conflicting results in different populations on the role of genes that constitute risk factors suggest the presence of real biological differences. The association of CP/NTD in an area with a high prevalence of NTDs can identify a group of conditions that can be considered etiologically homogeneous. The epidemiological evaluation can guide genetic research to specify the role of etiological factors in each different population (literal)

Editore