Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (Articolo in rivista)

Type
Label
  • Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.mrfmmm.2008.08.011 (literal)
Alternative label
  • Silvana Simi; Michela Ballardin; Marta Casella; Daniele De Marchi; Valentina Hartwig; Giulio Giovannetti; Nicola Vanello; Sabrina Gabbriellini; Luigi Landini; Massimo Lombardi (2008)
    Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan
    in Mutation research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Silvana Simi; Michela Ballardin; Marta Casella; Daniele De Marchi; Valentina Hartwig; Giulio Giovannetti; Nicola Vanello; Sabrina Gabbriellini; Luigi Landini; Massimo Lombardi (literal)
Pagina inizio
  • 39 (literal)
Pagina fine
  • 43 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 645 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cell Biology and Cytogenetics Unit, Institute of Clinical Physiology, C.N.R., Pisa, Italy Magnetic Resonance Laboratory, Institute of Clinical Physiology, C.N.R., Pisa, Italy ITENI Laboratory, Institute of Clinical Physiology, C.N.R., Pisa, Italy Department of Electric Systems and Automation, University of Pisa, Italy Department of Information Engineering, University of Pisa, Italy (literal)
Titolo
  • Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (literal)
Abstract
  • Magnetic resonance imaging is a diagnostic technique widely used in medicine and showing a growing impact in cardiology. Biological effects associated to magnetic resonance electromagnetic fields have received far little attention, but it cannot be ruled out that these fields can alter DNA structure. The present study aimed at to identify possible DNA damage induced by magnetic resonance scan in humans. Lymphocyte cultures from healthy subjects had been exposed into magnetic resonance device for different times and under different variable magnetic exposure in order to build dose-effect curves, using micronuclei induction as biological marker. Replicate cultureswere also left for 24 h at room temperature before stimulation, to verify possible damage recovery. Furthermore, micronuclei induction and recovery up to 120 h have been also evaluated in circulating lymphocytes of individuals after cardiac scan. A dose-dependent increase of micronuclei frequency was observed in vitro. However after 24 h, the frequency returns to control value when the exposure is within diagnostic dosage. After in vivo scan, a significant increase in micronuclei is found till 24 h, after the frequencies slowly return to control value. (literal)
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