http://www.cnr.it/ontology/cnr/individuo/prodotto/ID181848
Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (Articolo in rivista)
- Type
- Label
- Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.mrfmmm.2008.08.011 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Silvana Simi; Michela Ballardin; Marta Casella; Daniele De Marchi; Valentina Hartwig;
Giulio Giovannetti; Nicola Vanello; Sabrina Gabbriellini; Luigi Landini; Massimo Lombardi (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Cell Biology and Cytogenetics Unit, Institute of Clinical Physiology, C.N.R., Pisa, Italy
Magnetic Resonance Laboratory, Institute of Clinical Physiology, C.N.R., Pisa, Italy
ITENI Laboratory, Institute of Clinical Physiology, C.N.R., Pisa, Italy
Department of Electric Systems and Automation, University of Pisa, Italy
Department of Information Engineering, University of Pisa, Italy (literal)
- Titolo
- Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan (literal)
- Abstract
- Magnetic resonance imaging is a diagnostic technique widely used in medicine and showing a growing
impact in cardiology. Biological effects associated to magnetic resonance electromagnetic fields have
received far little attention, but it cannot be ruled out that these fields can alter DNA structure. The
present study aimed at to identify possible DNA damage induced by magnetic resonance scan in humans.
Lymphocyte cultures from healthy subjects had been exposed into magnetic resonance device for different
times and under different variable magnetic exposure in order to build dose-effect curves, using
micronuclei induction as biological marker. Replicate cultureswere also left for 24 h at room temperature
before stimulation, to verify possible damage recovery.
Furthermore, micronuclei induction and recovery up to 120 h have been also evaluated in circulating
lymphocytes of individuals after cardiac scan.
A dose-dependent increase of micronuclei frequency was observed in vitro. However after 24 h, the
frequency returns to control value when the exposure is within diagnostic dosage. After in vivo scan, a
significant increase in micronuclei is found till 24 h, after the frequencies slowly return to control value. (literal)
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