Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ejphar.2005.05.006 (literal)

Alternative label

• Mascia MP; Asproni B; Busonero F;Talani G; Maciocco E; Pau A; Cerri R;Sanna E; Biggio G (2005)
  Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
  in European journal of pharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mascia MP; Asproni B; Busonero F;Talani G; Maciocco E; Pau A; Cerri R;Sanna E; Biggio G (literal)

Rivista

• European journal of pharmacology (Rivista)

Note

• PubMe (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Sezione di Cagliari, Italy Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Sassari, Italy Dipartimento di Biologia Sperimentale \"B. Loddo,\" and Centro di Eccellenza per le Dipendenze, Università di Cagliari, Cagliari, Italy (literal)

Titolo

• Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. (literal)

Abstract

• Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate (TG41) enhanced the binding both of gamma-aminobutyric acid (GABA) and of flunitrazepam to rat cerebral cortical membranes. Electrophysiological recordings from Xenopus oocytes expressing various recombinant GABA(A) receptor subtypes revealed that TG41 enhanced the function of all receptor subunit combinations tested. The potency of TG41 at receptors containing alpha1, beta2, and gamma2L subunits was greater than that of alphaxalone, etomidate, propofol, or pentobarbital. The potency of TG41 was also greater at receptors containing alpha1 or alpha2 subunits than at those containing alpha4 and it was markedly higher at receptors containing beta2 or beta3 subunits than at those containing beta1. This drug induced a reversible loss of the righting reflex in Xenopus tadpoles and it elicited hypnosis (5 mg/kg) after intravenous administration in rats. These results indicate that the pharmacological profile of TG41 is similar to that of general anesthetics which potentiate the activity of GABA(A) receptors containing the beta2 or beta3 subunit. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• GIOVANNI BIGGIO (Unità di personale esterno)
• GIUSEPPE TALANI (Persona)
• ELISABETTA MACIOCCO (Unità di personale interno)
• MARIA PAOLA MASCIA (Persona)

Insieme di parole chiave

• Keywords of "Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA PAOLA MASCIA (Persona)
• ELISABETTA MACIOCCO (Unità di personale interno)
• GIOVANNI BIGGIO (Unità di personale esterno)
• GIUSEPPE TALANI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of pharmacology (Rivista)

Insieme di parole chiave di

• Keywords of "Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors." (Insieme di parole chiave)