Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00259-003-1381-0 (literal)

Alternative label

• Luigi Aloj, Antonella Zannetti, Corradina Caracó, Silvana Del Vecchio, Marco Salvatore (2004)
  Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines
  in European journal of nuclear medicine and molecular imaging (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Luigi Aloj, Antonella Zannetti, Corradina Caracó, Silvana Del Vecchio, Marco Salvatore (literal)

Pagina inizio

• 521 (literal)

Pagina fine

• 527 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• European journal of nuclear medicine and molecular imaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche (CNR), Napoli Dipartimento di Scienze Biomorfologiche e Funzionali, Universita' \"Federico II\", Napoli, Italy (literal)

Titolo

• Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (literal)

Abstract

• We have previously shown a correlation be- tween the absence of technetium-99m methoxyisobutyl- isonitrile (99mTc-MIBI) uptake and overexpression of the anti-apoptotic protein Bcl-2 in human breast carcinoma. To establish a direct cause-effect relationship between Bcl-2 overexpression and reduced 99mTc-MIBI uptake, MCF-7 and T47D breast cancer cell lines were stably transfected with the human Bcl-2 gene to increase intra- cellular protein levels and tested for 99mTc-MIBI uptake. All clones overexpressing Bcl-2 showed a dramatic re- duction of 99mTc-MIBI uptake as compared with mock transfected control cells. Tracer uptake was promptly and partially restored by induction of apoptosis with staurosporine treatment. After 4.5 h of staurosporine treatment, a tenfold increase in 99mTc-MIBI uptake was observed in treated as compared with untreated Bcl-2 overexpressing cells. Our findings provide a rational ba- sis for the development of an in vivo test to detect Bcl-2 overexpression in human tumours. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Autore CNR

• MARCO SALVATORE (Persona)
• ANTONELLA ZANNETTI (Unità di personale interno)
• SILVANA DEL VECCHIO (Unità di personale esterno)

Incoming links:

Autore CNR di

• MARCO SALVATORE (Persona)
• ANTONELLA ZANNETTI (Unità di personale interno)
• SILVANA DEL VECCHIO (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of nuclear medicine and molecular imaging (Rivista)