http://www.cnr.it/ontology/cnr/individuo/prodotto/ID18150
Poly(3-hydroxybutyrate-co-E-caprolactone) copolymers and poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-E-caprolactone) terpolymers as novel materials for colloidal drug delivery systems (Articolo in rivista)
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- Poly(3-hydroxybutyrate-co-E-caprolactone) copolymers and poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-E-caprolactone) terpolymers as novel materials for colloidal drug delivery systems (Articolo in rivista) (literal)
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- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.ejps.2009.03.017 (literal)
- Alternative label
R.Pignatello, T.Musumeci, G.Impallomeni, G.M.Carnemolla, G.Puglisi, A.Ballistreri (2009)
Poly(3-hydroxybutyrate-co-E-caprolactone) copolymers and poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-E-caprolactone) terpolymers as novel materials for colloidal drug delivery systems
in European journal of pharmaceutical sciences
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- R.Pignatello, T.Musumeci, G.Impallomeni, G.M.Carnemolla, G.Puglisi, A.Ballistreri (literal)
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- R.Pignatello, T.Musumeci,G.Puglisi. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, Città Universitaria, Viale A. Doria, 6, I-95125 Catania, Italy
G.M.Carnemolla,A.Ballistreri. Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Città Universitaria, Viale A. Doria, 6, I-95125 Catania, Italy (literal)
- Titolo
- Poly(3-hydroxybutyrate-co-E-caprolactone) copolymers and poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-E-caprolactone) terpolymers as novel materials for colloidal drug delivery systems (literal)
- Abstract
- Poly(3-hydroxybutyrate-co-?-caprolactone) copolymers and poly(3-hydroxybutyrate-co-3-
hydroxyvalerate-co-?-caprolactone) terpolymers were used by a solvent deposition technique to
prepare either micro- or nanoparticles. In particular, the synthesis and analytical characterization of the
terpolymers were described.
On the basis of copolymer composition and properties, either micro- or nanoparticles were obtained;
nanoparticle size was below 500nm for the suspensions obtained from P(HB-co-CL) copolymers, and
even smaller (200-300 nm) for those obtained using terpolymers. Particle size showed only a limited
tendency to increase during storage, suggesting a good chemical and physical stability in the short-term
storage at roomtemperature.Somecopolymers producedhetero-dispersed microparticles under thesame
conditions, with a mean size between 10 and 30?m. These systems showed a tendency to aggregate upon
storage at room temperature.
The nanoparticles showed a negative surface charge (around -20mVfor those prepared using an Ultra-
Turrax and about -5mV for those prepared by magnetic stirring). After storage at 4 oC the surface charge
tend to decrease and these changes have been explained in terms of a partial hydrolysis of the polymeric
matrix in aqueous suspension, which led to a change of chemical composition at the surface of the
particles.
The fluorescent probes calcein and Oil Red O were encapsulated in these systems as models of a
hydrophilic and lipophilic drug molecule, respectively. Encapsulation efficiency and in vitro release profiles
were studied to evaluate the effect of copolymer properties, such as molecular weight and composition,
on their behaviour as potential materials to prepare controlled drug delivery carriers. Calcein was generally
better encapsulated (up to 100%) than Oil Red O (10-30%); however, the ?-potential measurement
and in vitro release experiments suggested that a large amount of calcein was adsorbed onto the particle
surface and was rapidly released within the first minutes of the test. Conversely, the lipophilic probe was
dispersed within the polymeric matrix and its release profile from the nanoparticles was characterized
by a considerable lag time (up to 8 h), followed by a slow and almost linear release.
As a general trend, we observed that the composition and crystallinity of the tested polymers affected
the type and size of obtained systems (micro- or nanoparticles), whereas the molecular weight mainly
influenced the probes encapsulation and release. (literal)
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