Macromolecular properties of cepacian in water and in dimethylsulfoxide (Articolo in rivista)

Type
Label
  • Macromolecular properties of cepacian in water and in dimethylsulfoxide (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.carres.2007.10.003 (literal)
Alternative label
  • Y. Herasimenka; P. Cescutti; C. E. Sampaio Noguera; J. R. Ruggiero; R. Urbani; G. Impallomeni; F. Zanetti; S. Campidelli; M. Prato; R. Rizzo. (2008)
    Macromolecular properties of cepacian in water and in dimethylsulfoxide
    in Carbohydrate research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Y. Herasimenka; P. Cescutti; C. E. Sampaio Noguera; J. R. Ruggiero; R. Urbani; G. Impallomeni; F. Zanetti; S. Campidelli; M. Prato; R. Rizzo. (literal)
Pagina inizio
  • 81 (literal)
Pagina fine
  • 89 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 343 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Y. Herasimenka; P. Cescutti; R. Urbani; R. Rizzo. Department of Biochemistry, Biophysics and Macromolecules Chemistry, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy. C. E. Sampaio Noguera; J. R. Ruggiero. UNESP Sao Paulo State University, Department of Physics, IBILCE, Sao Jose do Rio Preto, Brazil. F. Zanetti. Eurand S.p.A., Area Science Park, Padriciano 99, 34012 Trieste, Italy. S. Campidelli; M. Prato. Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy. (literal)
Titolo
  • Macromolecular properties of cepacian in water and in dimethylsulfoxide (literal)
Abstract
  • Cepacian is the exopolysaccharide produced by the majority of the so far investigated clinical strains of the Burkholderia cepacia complex. This is a group of nine closely related bacterial species that might cause serious lung infections in cystic fibrosis patients, in some cases leading to death. In this paper the aggregation ability and the conformational properties of cepacian chain were investigated to understand its role in biofilm formation. Viscosity and atomic force microscopy studies in water and in mixed (dimethylsulfoxide/water) solvent indicated the formation of double stranded molecular structures in aqueous solutions. Inter-residue short distances along cepacian chain were investigated by NOE NMR, which showed that two side chains of cepacian were not conformationally free due to strong interactions with the polymer backbone. These interactions were attributed to hydrogen bonding and contributed to structure rigidity. (literal)
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