BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.neuroscience.2010.08.067 (literal)

Alternative label

• S. MARINELLI,a; S. LUVISETTO,a; S. COBIANCHI,a; W. MAKUCH,b; I. OBARA,b; E. MEZZAROMA,c; M. CARUSO,c; E. STRAFACE,d; B. PRZEWLOCKA,b AND F. PAVONE,a (2010)
  BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS
  in Neuroscience; Pergamon-Elsevier Press Science LDT, Oxford (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. MARINELLI,a; S. LUVISETTO,a; S. COBIANCHI,a; W. MAKUCH,b; I. OBARA,b; E. MEZZAROMA,c; M. CARUSO,c; E. STRAFACE,d; B. PRZEWLOCKA,b AND F. PAVONE,a (literal)

Pagina inizio

• 316 (literal)

Pagina fine

• 328 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0306452210012170 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 171 (literal)

Rivista

• Neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 13 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a - CNR, Institute of Neuroscience, Via del Fosso di Fiorano 64, 00143, Roma, Italy; b - Department of Pain Pharmacology, Institute of Pharmacology, 12 Smetna Street, 31-343 Krakow, Poland; c - CNR, Institute of Neurobiology and Molecular Medicine, Via del Fosso di Fiorano 64, 00143 Roma, Italy; d - Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy (literal)

Titolo

• BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS (literal)

Abstract

• A growing interest was recently focused on the use of Botulinum neurotoxin serotype A (BoNT/A) for fighting pain. The aim of this study was to investigate the effects of BoNT/A on neuropathic pain. It was observed that BoNT/A is able to counteract neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve both in mice and in rats. This effect is already present after a single intraplantar (i.pl.) or intrathecal (i.t.) neurotoxin administration that significantly reduces the sciatic nerve ligation-induced mechanical allodynia in mice and rats and thermal hyperalgesia in rats. This effect was evident starting 24 h after the administration of BoNT/A and it was long-lasting, being present 81 or 25 days after i.pl. injection of the higher dose in mice (15 pg/paw) and rats (75 pg/paw), respectively, and 35 days after i.t. injection in rats (75 pg/rat). Moreover, BoNT/A-injected mice showed a quicker recovery of the walking pattern and weight bearing compared to control groups. The behavioral improvement was accompanied by structural modifications, as revealed by the expression of cell division cycle 2 (Cdc2) and growth associated protein 43 (GAP-43) regeneration associated proteins, investigated by immunofluorescence and Western blotting in the sciatic nerve, and by the immunofluorescence expression of S100_ and glial fibrillary acidic protein (GFAP) Schwann cells proteins. In conclusion, the present research demonstrate long-lasting anti-allodynic and anti-hyperalgesic effects of BoNT/A in animal models of neuropathic pain together with an acceleration of regenerative processes in the injured nerve, as evidenced by both behavioral and immunohistochemistry/blotting analysis. These results may have important implications in the therapy of neuropathic pain. © 2010 IBRO. Published by Elsevier Ltd. All rights reserved (literal)

Editore

• Pergamon-Elsevier Press Science LDT (Editore)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• SARA MARINELLI (Persona)
• FLAMINIA PAVONE (Unità di personale interno)
• MAURIZIA CARUSO (Persona)
• SIRO LUVISETTO (Persona)

Insieme di parole chiave

• Parole chiave di "BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS" (Insieme di parole chiave)

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Autore CNR di

• MAURIZIA CARUSO (Persona)
• FLAMINIA PAVONE (Unità di personale interno)
• SIRO LUVISETTO (Persona)
• SARA MARINELLI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience (Rivista)

Editore di

• Pergamon-Elsevier Press Science LDT (Editore)

Insieme di parole chiave di

• Parole chiave di "BOTULINUM NEUROTOXIN TYPE A COUNTERACTS NEUROPATHIC PAIN AND FACILITATES FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY IN ANIMAL MODELS" (Insieme di parole chiave)