Inflammation, genes and zinc in Alzheimer's disease. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Inflammation, genes and zinc in Alzheimer's disease. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.brainresrev.2007.12.001 (literal)

Alternative label

• Vasto S; Candore G; Listì F; Balistreri CR; Colonna-Romano G; Malavolta M; Lio D; Nuzzo D; Mocchegiani E; Di Bona D; Caruso C (2008)
  Inflammation, genes and zinc in Alzheimer's disease.
  in Brain research reviews
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vasto S; Candore G; Listì F; Balistreri CR; Colonna-Romano G; Malavolta M; Lio D; Nuzzo D; Mocchegiani E; Di Bona D; Caruso C (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• Jun;58(1) (literal)

Rivista

• Brain research reviews (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ibim cnr (literal)

Titolo

• Inflammation, genes and zinc in Alzheimer's disease. (literal)

Abstract

• Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. AD has been linked to inflammation and metal biological pathway. Neuro-pathological hallmarks are senile plaques, resulting from the accumulation of several proteins and an inflammatory reaction around deposits of amyloid, a fibrillar protein,A?, product of cleavage of amuchlarger protein, the ?-amyloid precursor protein (APP) and neurofibrillary tangles. Amyloid deposition, due to the accumulation of A? peptide, is the main pathogenetic mechanism. Inflammation clearly occurs in pathologically vulnerable regions of AD and several inflammatory factors influencing AD development, i.e. environmental factors (pro-inflammatory phenotype) and/ or genetic factors (pro-inflammatory genotype) have been described. At the biochemical level metals such as zinc are known to accelerate the aggregation of theamyloid peptide and play a role in the control of inflammatory responses. In particular, zinc availability may regulate mRNA cytokine expression, so influencing inflammatory network phenotypic expression. (literal)

Prodotto di

• Processi di aggregazione, misfolding di proteine e neuropatologie (ME.P02.021.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• DOMENICO NUZZO (Persona)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Processi di aggregazione, misfolding di proteine e neuropatologie (ME.P02.021.001) (Modulo)

Autore CNR di

• DOMENICO NUZZO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain research reviews (Rivista)