A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/mabi.200500114 (literal)

Alternative label

• A. La Gatta; A. De Rosa; P. Laurienzo; M. Malinconico; M. De Rosa; C. Schiraldi (2005)
  A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization
  in Macromolecular bioscience (Print); Wiley-VCH Verlag Gmbh, Weinheim (Germania)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. La Gatta; A. De Rosa; P. Laurienzo; M. Malinconico; M. De Rosa; C. Schiraldi (literal)

Pagina inizio

• 1108 (literal)

Pagina fine

• 1117 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Macromolecular bioscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• No. Citazione=0; Autocitazione=0; Motore utilizzato per le citazioni=Google Scholar. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopus (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• A. La Gatta, A. De Rosa, M. De Rosa, C. Schiraldi Department of Experimental Medicine, Faculty of Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy (literal)

Titolo

• A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization (literal)

Abstract

• A novel poly(e-caprolactone)/calcium sulfate system was prepared and characterized in order to enhance calcium sulfate (gypsum) performance as bone graft substitute overcoming its brittleness and fast resorption rate. A poly(e-caprolactone) (PCL) photo-crosslinkable derivative (PCLf) was synthesized by reaction of a low molecular weight PCL diol with methacryloyl chloride and confirmed by FT-IR and 1H NMR analyses. An injectable and easy mouldable mixture of PCLf and calcium sulfate hemi-hydrate (PCLf/CHS) was obtained. Thermal analyses and solvent extraction proved the occurrence of PCLf photo-crosslinking, even in the presence of CHS, in a time suitable for clinical applications. Swelling studies demonstrated that the encapsulation of the inorganic filler increases network hydrophilicity making it more permeable to water. Scanning electron microscopy, performed on crosslinked PCLf/CHS and on the same material after incubation in a PBS solution, showed the feasibility to obtain, in situ, gypsum entrapped into a degradable polymeric network. In vitro cytotoxicity tests, performed according to ISO 10993-5, proved that the developed system was not cytotoxic supporting its potential use in tissue engineering as a new, injectable, photocurable bone graft material. (literal)

Editore

• Wiley-VCH Verlag Gmbh (Editore)

Prodotto di

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• 2. Sintesi di polimeri e progettazione di sistemi polimerici biomimetici per lo sviluppo ecosostenibile (PM.P02.002.001) (Modulo)

Autore CNR

• PAOLA LAURIENZO (Persona)
• MARIO MALINCONICO (Persona)

Insieme di parole chiave

• Parole chiave di "A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• PAOLA LAURIENZO (Persona)
• MARIO MALINCONICO (Persona)

Prodotto

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• 2. Sintesi di polimeri e progettazione di sistemi polimerici biomimetici per lo sviluppo ecosostenibile (PM.P02.002.001) (Modulo)

Editore di

• Wiley-VCH Verlag Gmbh (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Macromolecular bioscience (Rivista)

Insieme di parole chiave di

• Parole chiave di "A Novel Injectable Poly(epsilon-caprolactone)/Calcium Sulphate System for Bone Regeneration: Synthesis and Characterization" (Insieme di parole chiave)