Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1046/j.1471-4159.2000.0750018.x (literal)

Alternative label

• Flora, A; Schulz, R; Benfante, R; Battaglioli, E ; Terzano, S; Clementi, F; Fornasari, D (2000)
  Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene
  in Journal of neurochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Flora, A; Schulz, R; Benfante, R; Battaglioli, E ; Terzano, S; Clementi, F; Fornasari, D (literal)

Pagina inizio

• 18 (literal)

Pagina fine

• 27 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 75 (literal)

Rivista

• Journal of neurochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. CNR - Istituto di Neuroscienze, Milano 2. Università degli Studi di Milano, Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Milano (literal)

Titolo

• Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene (literal)

Abstract

• The mRNA encoding the human alpha 5 nicotinic subunit was detected in several structures of the nervous system but appeared to be mainly expressed in cerebellum, thalamus, and the autonomic ganglia. For the first time, the alpha 5 transcript was also detected in several nonneuronal tissues, with maximal expressions being found throughout the gastrointestinal tract, thymus, and testis. Many other extraneuronal sites expressed alpha 5, but there were also nonexpressing organs, such as the liver, spleen, and kidney. To understand the transcriptional mechanisms controlling such a diversified expression of alpha 5 in neuronal and nonneuronal cells, we isolated the 5'-regulatory region of the human gene and characterized its properties. Here we identify the alpha 5 core promoter and demonstrate that the DNA regions surrounding it contain elements (with positive or negative activities) that work in a tissue-specific fashion. In particular, the segment specifying the 5'-untranslated region in neuronal cells has most of the properties of an enhancer because it activates a heterologous promoter in a position- and orientation-independent fashion. We therefore conclude that the expression of alpha 5 relies on a highly complex promoter that uses distinct regulatory elements to comply with the different functional and developmental requirements of the various tissues and organs. (literal)

Prodotto di

• Modulazione recettoriale del differenziamento cellulare (ME.P03.004.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• ROBERTA BENFANTE (Unità di personale interno)
• DIEGO MARIA MICHELE FORNASARI (Persona)
• FRANCESCO CLEMENTI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCO CLEMENTI (Unità di personale esterno)
• DIEGO MARIA MICHELE FORNASARI (Persona)
• ROBERTA BENFANTE (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modulazione recettoriale del differenziamento cellulare (ME.P03.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurochemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Neuronal and extraneuronal expression and regulation of the human alpha 5 nicotinic receptor subunit gene" (Insieme di parole chiave)