Peptides Targeting Angiogenesis Related Growth Factor Receptors (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Peptides Targeting Angiogenesis Related Growth Factor Receptors (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• D'Andrea, LD; Del Gatto, A; De Rosa, L; Romanelli, A; Pedone, C (2009)
  Peptides Targeting Angiogenesis Related Growth Factor Receptors
  in Current pharmaceutical design (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Andrea, LD; Del Gatto, A; De Rosa, L; Romanelli, A; Pedone, C (literal)

Pagina inizio

• 2414 (literal)

Pagina fine

• 2429 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Current pharmaceutical design (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• D'Andrea, LD; Del Gatto, A; De Rosa, L; Istituto di Biostrutture e Bioimmagini, CNR Romanelli, A; Pedone, C; Università di Napoli \"Federico II\" (literal)

Titolo

• Peptides Targeting Angiogenesis Related Growth Factor Receptors (literal)

Abstract

• Growth factors (GFs) are extracellular signaling polypeptides regulating cell proliferation, differentiation and survival. They exert a wide spectrum of biological activities selectively binding to and activating specific membrane receptors which then transfer the message to cell interior inducing specific biochemical pathways. GFs are especially involved in the regulation of angiogenesis, a physiological process underlining several pathologies. Molecules able to modulate angiogenesis, interfering with the molecular recognition between a GF and its receptor, have a big pharmacologic interest. Either GF and the receptor are potential drug target. Peptides are useful molecules to develop new lead compounds disrupting protein-protein interface for pharmacological applications. In this review we describe peptides targeting the receptors of the pro-angiogenic growth factors FGF, PDGF and VEGF. The biological function and the structure of each growth factor/receptor system are discussed, as well as the molecular interaction between peptides and the receptors. Finally, we highlight the pharmacological and diagnostic applications of these peptides in angiogenesis related diseases. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sistemi sintetici riconoscibili da target biologici (PM.P01.003.001) (Modulo)

Autore CNR

• ANNARITA DEL GATTO (Persona)
• LUCA DOMENICO D'ANDREA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Peptides Targeting Angiogenesis Related Growth Factor Receptors" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sistemi sintetici riconoscibili da target biologici (PM.P01.003.001) (Modulo)

Autore CNR di

• LUCA DOMENICO D'ANDREA (Unità di personale interno)
• ANNARITA DEL GATTO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current pharmaceutical design (Rivista)

Insieme di parole chiave di

• Parole chiave di "Peptides Targeting Angiogenesis Related Growth Factor Receptors" (Insieme di parole chiave)