MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1074/jbc.M311793200 (literal)

Alternative label

• Mancini F; Gentiletti F; D'Angelo M; Giglio S; Nanni S; D'Angelo C; Farsetti A; Citro G; Sacchi A; Pontecorvi A; Moretti F (2004)
  MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis
  in The Journal of biological chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mancini F; Gentiletti F; D'Angelo M; Giglio S; Nanni S; D'Angelo C; Farsetti A; Citro G; Sacchi A; Pontecorvi A; Moretti F (literal)

Pagina inizio

• 8169 (literal)

Pagina fine

• 8180 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2003 Dec 1. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.jbc.org/content/279/9/8169.full.pdf+html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 279 (literal)

Rivista

• ?The ?Journal of biological chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Regina Elena Inst Canc Res, Lab Mol Oncogenesis, I-00158 Rome, Italy 2. Regina Elena Inst Canc Res, Lab Expt Chemotherapy, I-00158 Rome, Italy 3. Regina Elena Inst Canc Res, Anim House Serv, I-00158 Rome, Italy 4. Catholic Univ, Inst Med Pathol, I-00100 Rome, Italy 5. CNR, Neurobiol & Mol Med Inst, I-00137 Rome, Italy (literal)

Titolo

• MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis (literal)

Abstract

• Rescue of embryonic lethality in MDM4(-/-) mice through concomitant loss of p53 has revealed a functional partnership between the two proteins. Biochemical studies have suggested that MDM4 may act as a negative regulator of p53 levels and activity. On the other hand, MDM4 overexpression has been reported to stabilize p53 levels and to counteract MDM2-degradative activity. We have investigated the functional role of MDM4 overexpression on cell behavior. In both established and primary cells cultured under stress conditions, overexpression of MDM4 significantly increased p53-dependent cell death, in correlation with enhanced induction of the endogenous p53 protein levels. This phenomenon was associated with induced p53 transcriptional activity and increased levels of the proapoptotic protein, Bax. Further, p53 stabilization was accompanied by decreased association of the protein to its negative regulator, MDM2. These findings reveal a novel role for MDM4 by demonstrating that in non-tumor cells under stress conditions it may act as a positive regulator of p53 activity, mainly by controlling p53 levels. They also indicate a major distinction between the biological consequences of MDM4 and MDM2 overexpression. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• FABIOLA MORETTI (Unità di personale interno)
• ANTONELLA FARSETTI (Persona)

Incoming links:

Autore CNR di

• FABIOLA MORETTI (Unità di personale interno)
• ANTONELLA FARSETTI (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of biological chemistry (Rivista)