http://www.cnr.it/ontology/cnr/individuo/prodotto/ID179588

Overexpression of the phosphoprotein enriched in diabetes gene product (PED/PEA15) in women with polycistic ovary sindrome. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Overexpression of the phosphoprotein enriched in diabetes gene product (PED/PEA15) in women with polycistic ovary sindrome. (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/j.1365-2265.2007.02924.x (literal)

Alternative label

S.Savastano; F.Orio; S.Palomba; T.Cascella; G.A.Lupoli; P.Formisano; G.Lombardi; A.M.Colao; F.Beguinot; R.Valentino (2007)
Overexpression of the phosphoprotein enriched in diabetes gene product (PED/PEA15) in women with polycistic ovary sindrome.
in Clinical endocrinology (Oxf., Print); Blackwell Publishing, Oxford (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

S.Savastano; F.Orio; S.Palomba; T.Cascella; G.A.Lupoli; P.Formisano; G.Lombardi; A.M.Colao; F.Beguinot; R.Valentino (literal)

Pagina inizio

557 (literal)

Pagina fine

562 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

67 (literal)

Rivista

Clinical endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Molecular and Clinical Endocrinology and Oncology, University 'Federico II', Naples, Italy, Department of Obstetrics and Gynecology, University 'Magna Graecia', Catanzaro, Italy, Department of Clinical and Experimental Medicine, Gastroenterology Unit and C.N.R. Institute of Experimental Endocrinology and Oncology 'G. Salvatore', Department of Cellular and Molecular Biology and Pathology, University 'Federico II', Naples, Italy (literal)

Titolo

Overexpression of the phosphoprotein enriched in diabetes gene product (PED/PEA15) in women with polycistic ovary sindrome. (literal)

Abstract

Objective To evaluate Ped/pea-15 (phosphoprotein enriched in diabetes) expression in polycystic ovary syndrome (PCOS) women. Design and patients Thirty PCOS women were studied and compared with other 30 age- and body mass index (BMI)-matched women, considered as the control group. Both patients and controls were divided according to BMI. All subjects underwent endocrine and metabolic investigation and Ped/pea-15 expression was evaluated by western blot analysis. Insulin resistance was assessed by HOMA model and insulin sensitivity index (ISI) composite. Results Insulin resistance, evaluated by HOMA-R and ISI composite, was significantly higher in PCOS women and in obese controls than in normal weight controls. Ped/pea-15 expression (%) was higher in PCOS women than in controls (440·4 ± 220·7 vs. 163·0 ± 45·5; P < 0·001; range 145·5-987% and 97-281%, respectively), and was positively correlated with insulin, BMI, total testosterone, HOMA index, and family history ( P < 0·001). In patients with PCOS univariate analysis of variance showed no effect of BMI variation ( P = 0·13) on Ped/pea-15 expression levels. On multiple linear regression analysis, the major determinants of Ped/pea-15 overexpression were family history, insulin, and PCOS status independent of BMI. Conclusion These preliminary data (1) highlight the overexpression of Ped/pea-15 in PCOS compared to normal controls, independent of obesity; (2) suggest that Ped/pea-15 overexpression might be an early component of the metabolic syndrome in PCOS; and (3) support the hypothesis that Ped/pea-15 represents a possible useful tool to assess the presence of a genetic condition associated with insulin resistance in PCOS. (literal)

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