Hypoallergenic fragment of Parj2 increases functional expression of toll like receptors in atopic children (Articolo in rivista)

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  • Hypoallergenic fragment of Parj2 increases functional expression of toll like receptors in atopic children (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1398-9995.2006.01234.x (literal)
Alternative label
  • Pace, E. (1); Duro, G. (1); La Grutta, S.(1); Ferraro, M. (1); Bruno, A. (1); Bousquet, J. (2); Bonsignore, G. (1); Gjomarkaj, M. (1). (2006)
    Hypoallergenic fragment of Parj2 increases functional expression of toll like receptors in atopic children
    in Allergy (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pace, E. (1); Duro, G. (1); La Grutta, S.(1); Ferraro, M. (1); Bruno, A. (1); Bousquet, J. (2); Bonsignore, G. (1); Gjomarkaj, M. (1). (literal)
Pagina inizio
  • 1459 (literal)
Pagina fine
  • 1466 (literal)
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  • 61 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • PubMe (literal)
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  • (1) Istituto di Biomedicina e Immunologia Molecolare - Consiglio Nazionale Delle Ricerche; (2) Institut National de la Santè et de la Recherche Medical U-454 - (literal)
Titolo
  • Hypoallergenic fragment of Parj2 increases functional expression of toll like receptors in atopic children (literal)
Abstract
  • Background: Parietaria judaica (Par j) is one of the main causes of allergy in the Mediterranean countries. The activation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) inhibits nasal inflammation of atopic children. Objective: To examine, in vivo and in vitro, the effect of recombinant Par j 2 (rPar j 2) and of its fragments (1-55 and 52-102) on atopic children. Methods: We used skin prick test for in vivo evaluations. We assessed, in vitro, in peripheral blood mononuclear cells (PBMC), the effect of rPar j 2 and of the two fragments on neutrophil chemotaxis, on CD45RO, on TLR2 and TLR4 expression, on LPS binding and on interferon (IFN)-? release, by a microchemotaxis chamber, by flow cytometry and by enzyme-linked immunosorbent assay, respectively. Results: In vivo while rPar j 2 induced a positive skin reaction, 1-55 and 52-102 fragments did not. In vitro, while rPar j 2 increased both CD45RO expression and neutrophils chemotaxis in PBMC, both Par j 2 fragments did not. 1-55 fragment of Par j 2 upregulated both TLR2 and TLR4 expression and LPS binding, while the rPar j 2 and 52-102 fragment did not. Finally, 1-55 fragment of Par j 2 induced IFN? release, while the rPar j 2 and 52-102 fragment did not. Conclusions: Hypoallergenic 1-55 fragment, upregulating innate immunity receptors and increasing IFN?, might re-orientate, in atopics, the immune system toward a physiologic balance between Th1 and Th2 responses. (literal)
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