Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/bm0607630 (literal)

Alternative label

• M. Casolaro, I. Casolaro, A. Spreafico, C. Capperucci, B. Frediani, R. Marcolongo, N. Margiotta, R. Ostuni, R. Mendichi, F. Samperi, T. Ishii, Y. Ito (2006)
  Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues
  in Biomacromolecules
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Casolaro, I. Casolaro, A. Spreafico, C. Capperucci, B. Frediani, R. Marcolongo, N. Margiotta, R. Ostuni, R. Mendichi, F. Samperi, T. Ishii, Y. Ito (literal)

Pagina inizio

• 3417 (literal)

Pagina fine

• 3427 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Biomacromolecules (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• No. Citazione=1; Autocitazione=0; Motore utilizzato per le citazioni=Isiwebofknowledge.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Universita di Siena, Universita di Bari, The Institute of Physical and Chemical Research, Kanagawa Academy of Science and Technology. (literal)

Titolo

• Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues (literal)

Abstract

• Two poly(amido-amine)s (oligoPAM and oligoNER) contg. bis-phosphonate residues were obtained by a Michael-type polyaddn. of pamidronate and neridronate to 1,4-bis(acryloyl)piperazine. The SEC (size-exclusion chromatog.) and the MALDI-TOF (matrix assisted laser desorption ionization) analyses were consistent with the presence of oligomeric species (2-3 kDa) and with a narrow polydispersity index. The thermodn. results (log Ks, -? H° , and ? S° obtained at 25°C in 0.15 M NaCl) of both the oligomers and the corresponding low mol. wt. precursors were in line with a cluster structure formed during the protonation of the basic nitrogen in the pamidronate. The soly. of the oligoNER with a longer aliph. chain was improved at high pHs, allowing the evaluation of their soln. properties. Preliminary biol. results show that both the oligomers do not neg. affect the in vitro viability, proliferation, and cellular activity of either normal animal or human osteoblasts. (literal)

Prodotto di

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• 4. Sistemi polimerici innovativi ad elevate prestazioni per applicazioni biomediche ed ambientali (PM.P02.009.001) (Modulo)

Autore CNR

• FILIPPO SAMPERI (Persona)

Insieme di parole chiave

• Keywords of "Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FILIPPO SAMPERI (Persona)

Prodotto

• Istituto di chimica e tecnologia dei polimeri (ICTP) (Istituto)
• 4. Sistemi polimerici innovativi ad elevate prestazioni per applicazioni biomediche ed ambientali (PM.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomacromolecules (Rivista)

Insieme di parole chiave di

• Keywords of "Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amidoamine)s Containing Bis-phosphonate Residues" (Insieme di parole chiave)