Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study. (Articolo in rivista)

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  • Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/gerona/glp073 (literal)
Alternative label
  • Alberto Pilotto (1); Stefania Maggi (2); Marianna Noale (2); Marilisa Franceschi (1); Giancarlo Parisi (3); Gaetano Crepaldi (2) on behalf of the IPOD Investigators (2010)
    Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study.
    in The journals of gerontology. Series A, Biological sciences and medical sciences
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Alberto Pilotto (1); Stefania Maggi (2); Marianna Noale (2); Marilisa Franceschi (1); Giancarlo Parisi (3); Gaetano Crepaldi (2) on behalf of the IPOD Investigators (literal)
Pagina inizio
  • 174 (literal)
Pagina fine
  • 178 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 65 (literal)
Rivista
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  • 5 (literal)
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  • 2 (literal)
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  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1) Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy 2) Aging Section, Institute of Neurosciences, Department of Medicine, National Research Council, Padova, Italy 3) Department of Internal Medicine, General Hospital, Feltre, Italy (literal)
Titolo
  • Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study. (literal)
Abstract
  • Background. Several diagnostic questionnaires for evaluating upper gastrointestinal symptoms have been described; none of these, however, has been validated in older individuals. Objectives. To develop and validate a diagnostic tool for evaluating upper gastrointestinal symptoms in older patients. Methods. A cohort of 206 older patients who underwent a upper gastrointestinal endoscopy (development cohort) was used for developing a 15-item upper gastrointestinal symptom questionnaire for the elderly population (UGISQUE), including fi ve symptom clusters: (a) abdominal pain syndrome, (b) reflux syndrome, (c) indigestion syndrome, (d) bleeding, and (e) nonspecifi c symptoms. The questionnaire was then validated in a cohort of 326 older patients selected from those who underwent an upper gastrointestinal endoscopy in 15 gastroenterological centers in Italy (validation cohort). Results. The endoscopic diagnoses in the development and validation cohorts were esophagitis (E) 15.5% and 29.4%, erosive gastritis (EG) 24.8% and 24.8%, peptic ulcer (PU) 26.2% and 14.7%, and without organic lesions (WOL) 31.0% and 33.5%, respectively. In both the cohorts, patients with upper gastrointestinal disorders showed significantly more symptoms than WOL patients. The predictive value of UGISQUE for any pathological condition (E, EG, or PU) was good, with areas under the receiver-operating characteristic curve of .80, 95% confi dence interval (CI) 0.743 - 0.864, and of .78, 95% CI 0.73 - 0.83, in the development and validation cohorts, respectively. The accuracy of UGISQUE was significantly higher than that for the individual clusters of symptoms in predicting the presence of E (p=.004), PU (p<.0001), or any pathological condition (p<.0001). Conclusion. UGISQUE is an accurate diagnostic tool for evaluating symptoms in elderly patients with upper gastrointestinal disorders. (literal)
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