The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Kusmic Claudia; Basta Giuseppina; Lazzerini Guido; Vesentini Nicoletta; Barsacchi Renata (2004)
  The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis
  in Journal of cardiovascular pharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Kusmic Claudia; Basta Giuseppina; Lazzerini Guido; Vesentini Nicoletta; Barsacchi Renata (literal)

Pagina inizio

• 356 (literal)

Pagina fine

• 362 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 44 (literal)

Rivista

• Journal of cardiovascular pharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Institute of Clinical Physiology, CNR, PISA 2 Department of Physiology and Biochemistry, University of PISA (literal)

Titolo

• The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis (literal)

Abstract

• The effect of Ginkgo biloba extract (EGb 761) was studied in rat hearts submitted to ischemia/reperfusion. Isolated hearts perfused in Langendorff mode were subjected to 60 minutes of global ischemia and 15 minutes of reperfusion. EGb 761 was administered by chronic or acute treatment: intra-peritoneal injections of 5 mg/Kg extract for 5 days or 100 mg /L extract addition to the perfusion buffer, respectively. In hearts untreated with EGb 761 ischemia induced 20% decrease of membrane alpha-tocopherol concentration. This effect was not worsened by reperfusion. alpha-tocopherol consumption was accompanied by about 650% increase in 6-ketoPGF1alpha release within 3 minutes of reperfusion. Moreover, ischemia induced activation of transcription factor NF-kB. In both chronic and acute treatment with EGb 761 heart concentration of alpha-tocopherol was completely spared during ischemia as much as after reperfusion and a significant decrease of 6-ketoPGF1alpha release at 3 minutes of reperfusion was observed as compared with the untreated group. Nuclear translocation of NF-kB was lowered during ischemia. EGb 761 could act as direct free radical scavenger or as tocopheryl radical recycler; in both cases sparing membrane vitamin E should affect phospholipase A2 activity. Finally, EGb 761, by lowering ROS produced during ischemia, challenges nuclear translocation of NF-?B. (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• NICOLETTA VESENTINI (Unità di personale interno)
• CLAUDIA KUSMIC (Unità di personale interno)
• GIUSEPPINA BASTA (Persona)

Insieme di parole chiave

• Keywords of "The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR di

• GIUSEPPINA BASTA (Persona)
• CLAUDIA KUSMIC (Unità di personale interno)
• NICOLETTA VESENTINI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cardiovascular pharmacology (Rivista)

Insieme di parole chiave di

• Keywords of "The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart. A link between vitamin E preservation and prostaglandin biosynthesis" (Insieme di parole chiave)