Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (Articolo in rivista) (literal)

Anno

• 1998-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0378-1119(98)00254-6 (literal)

Alternative label

• Mantuano E; Trettel F; Olsen AS; Lennon G; Frontali M; Jodice C. (1998)
  Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1.
  in Gene (Amst.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mantuano E; Trettel F; Olsen AS; Lennon G; Frontali M; Jodice C. (literal)

Pagina inizio

• 153 (literal)

Pagina fine

• 157 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 215 (literal)

Rivista

• Gene (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Mantuano E; Frontali M. Istituto di Medicina Sperimentale CNR, Roam Italy Trettel F; Jodice C. Dipartimento di Biologia, Università Tor Vergata Roma, Italy Olsen AS; Lennon G. Biology and Biotechnology Research program, LLNL Livermore USA (literal)

Titolo

• Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. (literal)

Abstract

• The amino acid hypusine is formed post-translationally in a single cellular protein, the eukaryotic translation initiation factor 5A, by two enzymes, namely deoxyhypusine synthase and deoxyhypusine hydroxylase. Hypusine is found in all eukaryotes and in some archaebacteria, but not in eubacteria. The deoxyhypusine synthase cDNA was cloned and mapped by fluorescence in situ hybridization on chromosome 19p13.11-p13.12. Rare cDNAs containing internal deletions were also found. We localized the deoxyhypusine synthase gene on a high resolution cosmid/BAC contig map of chromosome 19 to a region in 19p13.2-distal 19p13.1 between MANB and JUNB. Analysis of the genomic exon/intron structure of the gene coding region showed that it consists of nine exons and spans a length of 6.6 kb. From observation of the genomic structure, it seems likely that the internally deleted forms of mature RNA are the result of alternative splicing, rather than of artifacts. (literal)

Prodotto di

• Neurogenetica e basi molecolari delle atassie spinocerebellari (SCA), atassie episodiche (EA), corea ereditaria benigna (BHC) e demenze associate a depressione e/o a disturbi psico-comportamentali. (ME.P02.026.001) (Modulo)

Autore CNR

• MARINA FRONTALI (Persona)
• ELIDE MANTUANO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ELIDE MANTUANO (Unità di personale interno)
• MARINA FRONTALI (Persona)

Prodotto

• Neurogenetica e basi molecolari delle atassie spinocerebellari (SCA), atassie episodiche (EA), corea ereditaria benigna (BHC) e demenze associate a depressione e/o a disturbi psico-comportamentali. (ME.P02.026.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gene (Rivista)

Insieme di parole chiave di

• Keywords of "Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1." (Insieme di parole chiave)