DNA methylation 40 years later: its role in human health and disease (Articolo in rivista)

Type
Label
  • DNA methylation 40 years later: its role in human health and disease (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/jcp.20280 (literal)
Alternative label
  • Scarano M.I.; Strazzullo M.; Matarazzo M.R.; D'Esposito M. (2005)
    DNA methylation 40 years later: its role in human health and disease
    in Journal of cellular physiology (Print); WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scarano M.I.; Strazzullo M.; Matarazzo M.R.; D'Esposito M. (literal)
Pagina inizio
  • 25 (literal)
Pagina fine
  • 35 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 204 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biomorphological and Functional Sciences, University of Naples ''Federico II'', Naples, Italy Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Sciences and Technology, Temple University, Philadelphia, Pennsylvania Institute of Genetics and Biophysics ''A. Buzzati Traverso'' via Marconi, Naples, Italy Biogem S.C.A.R.L., Ariano Irpino, Italy (literal)
Titolo
  • DNA methylation 40 years later: its role in human health and disease (literal)
Abstract
  • A long path, initiated more than 40 years ago, has led to a deeper understanding of the complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the imbalance in the epigenetic control of gene expression may profoundly alter the finely tuned machinery leading to gene regulation. Here, we review the impact of the studies on DNA methylation, the \"primadonna\" in the epigenetic scenario, on the understanding of basic phenomena, such as X inactivation and genomic imprinting. The effect of deregulation of DNA methylation on human health, will be also discussed. Finally, an attempt to predict future directions of this rapidly evolving field has been proposed, with the certainty that, fortunately, science is always better than predictions. (literal)
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