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Capillary electrophoresis-mass spectrometry: Recent trends in clinical proteomics (Articolo in rivista)

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Capillary electrophoresis-mass spectrometry: Recent trends in clinical proteomics (Articolo in rivista) (literal)

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Desiderio C.; Rossetti D.V.; Iavarone F.; Messana I.; Castagnola M. (2010)
Capillary electrophoresis-mass spectrometry: Recent trends in clinical proteomics
in Journal of pharmaceutical and biomedical analysis (Print)
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Claudia Desiderio(a), Diana Valeria Rossetti(b), Federica Iavarone(b), Irene Messana(c), Massimo Castagnola(a,b) (a) Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, c/o Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Roma, Italy (b) Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168 Roma, Italy (c) Dipartimento di Scienze Applicate ai Biosistemi, Università di Cagliari, Monserrato Campus, 09042 Monserrato (Ca), Italy (literal)

Titolo

Capillary electrophoresis-mass spectrometry: Recent trends in clinical proteomics (literal)

Abstract

The increasing attention now paid to the elucidation of human proteome strengthened the development of analytical instruments able to provide reliable proteins and peptides quantitation and characterization in biological fluids and tissues. Emerging from proteomics, clinical proteomics exclusively considers its biomedical applications. It evaluates, often by high-throughput comparative platforms, the protein and peptide variations in body fluids, cells and tissues under different physiological and pathological conditions with the aim of discovering disease biomarkers.Amongthe available analytical methodologies, mass spectrometry in coupling with liquid chromatography or capillary electrophoresis demonstrated to be the eligible technique for protein detection and identification. This review summarizes the most recent applications of capillary electrophoresis-mass spectrometry to clinical proteomics, focusing on capillary zone electrophoresis separation mode and ESI and MALDI ionizations, which are the most frequently applied capillary electrophoresis-mass spectrometry hyphenated techniques. (literal)

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