LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit. (Articolo in rivista)

Type
Label
  • LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s13105-012-0172-0 (literal)
Alternative label
  • Carlucci A.; Cigliano L.; Maresca B.; Spagnuolo M.S.; Di Salvo G.; Calabrò R.; Abrescia P (2012)
    LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit.
    in Journal of physiology and biochemistry; SPRINGER, DORDRECHT (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Carlucci A.; Cigliano L.; Maresca B.; Spagnuolo M.S.; Di Salvo G.; Calabrò R.; Abrescia P (literal)
Pagina inizio
  • 541 (literal)
Pagina fine
  • 553 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 68 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 13 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento delle Scienze Biologiche-Sezione di Fisiologia ed Igiene, Università di Napoli Federico II, via Mezzocannone 8, 80134, Naples, Italy Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo, Consiglio Nazionale delle Ricerche, Naples, Italy Dipartimento di Cardiologia, Divisione di Cardiologia Pediatrica, Seconda Università di Napoli, Ospedale Monaldi, Naples, Italy (literal)
Titolo
  • LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit. (literal)
Abstract
  • Apolipoprotein A-I and Apolipoprotein E promote different steps of reverse cholesterol transport, including lecithin-cholesterol acyltransferase stimulation. Our aim was to study the changes in the levels of Apolipoprotein A-I, Apolipoprotein E and lecithin-cholesterol acyltransferase activity during atherosclerosis progression in rabbits. Quantitative echocardiographic parameters were analysed in order to evaluate, for the first time, whether atherosclerosis progression in rabbit is associated to apolipoproteins changes and alteration of indices of cardiac function, such as systolic strain and strain rate of the left ventricle. Atherosclerosis was induced by feeding rabbits for 8 weeks with 2% cholesterol diet. The HDL levels of cholesterol and cholesteryl esters were measured by HPLC. The lecithin-cholesterol acyltransferase activity was evaluated both ex vivo, as cholesteryl esters / cholesterol molar ratio, and in vitro. Apolipoproteins levels were analysed by ELISA. The HDL levels of cholesterol and cholesteryl esters increased, during treatment, up to 3.7 and 2.5 fold respectively compared to control animals. The lecithin-cholesterol acyltransferase activity in vitro was halved after 4 weeks. During cholesterol treatment, Apolipoprotein A-I level significantly decreased, whereas Apolipoprotein E concentration markedly increased. The molar ratio Apolipoprotein E/Apolipoprotein A-I was negatively correlated with the enzyme activity, and positively correlated with both increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs, such as systolic strain and strain rate of the left ventricle. Further studies on humans or other animal models could be of help to confirm whether the ratio Apolipoprotein E/Apolipoprotein A-I can be considered as a biomarker of atherosclerosis progression. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it